Adrenal Gland Metastasis of a Gastrointestinal Stromal Tumor.
10.3904/kjm.2017.92.5.471
- Author:
Hyeon Jeong KANG
1
;
Hye Jin CHO
;
Kyung Hyun KIM
;
Mi Kyong JOUNG
;
Jae Uk SHIN
;
Su Sin JIN
Author Information
1. Department of Internal Medicine, The Catholic University of Korea College of Medicine, Seoul, Korea.
- Publication Type:Case Report
- Keywords:
Gastrointestinal stromal tumors;
Adrenal glands;
Metastasis;
Imatinib
- MeSH:
Adrenal Glands*;
Adrenalectomy;
Gastrointestinal Stromal Tumors*;
Humans;
Imatinib Mesylate;
Korea;
Lymph Nodes;
Male;
Middle Aged;
Neoplasm Metastasis*;
Peritoneum;
Recurrence
- From:Korean Journal of Medicine
2017;92(5):471-475
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
A 56-year-old male with a gastrointestinal stromal tumor (GIST) underwent surgical resection of the tumor. Nine months after surgery, imatinib therapy was initiated because of the discovery of metastatic tumors in the left adrenal gland and in a lymph node of the peritoneum. Seventeen months later, the patient achieved complete remission (CR) and imatinib therapy was continued. However, 48 months after initiation of imatinib therapy, computed tomography scans revealed a left adrenal gland metastasis and the patient underwent left adrenalectomy. Immunohistochemical staining indicated that the spindle-shaped cells of the resected tumor were positive for C-kit, thus confirming metastasis of the GIST. This is the first report from Korea of an adrenal gland metastasis from a GIST. Worldwide, only two such cases have been reported. Here, we describe the first case of a distant recurrence of a GIST in the left adrenal gland after CR had been achieved with the aid of surgical resection and imatinib therapy.
