No association between the IL28B SNP and response to peginterferon plus ribavirin combination treatment in Korean chronic hepatitis C patients.
10.3350/cmh.2014.20.2.177
- Author:
Nae Yun HEO
1
;
Young Suk LIM
;
Woochang LEE
;
Minkyung OH
;
Jiyun AN
;
Danbi LEE
;
Ju Hyun SHIM
;
Kang Mo KIM
;
Han Chu LEE
;
Yung Sang LEE
;
Dong Jin SUH
Author Information
1. Department of Internal Medicine, Haeundae Paik Hospital, Inje University College of Medicine, Busan, Korea.
- Publication Type:Original Article
- Keywords:
Chronic Hepatitis C;
Interleukin 28B;
Polymorphism, Single Nucleotide;
Korean
- MeSH:
Adult;
Alleles;
Antiviral Agents/*therapeutic use;
Asian Continental Ancestry Group/*genetics;
Cohort Studies;
Drug Therapy, Combination;
Female;
Gene Frequency;
Genotype;
Hepatitis C, Chronic/drug therapy/*genetics;
Humans;
Interferon-alpha/therapeutic use;
Interleukins/*genetics;
Linkage Disequilibrium;
Male;
Middle Aged;
Polyethylene Glycols/therapeutic use;
*Polymorphism, Single Nucleotide;
Recombinant Proteins/therapeutic use;
Republic of Korea;
Retrospective Studies;
Ribavirin/therapeutic use
- From:Clinical and Molecular Hepatology
2014;20(2):177-184
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND/AIMS: There are few available data regarding the association between the single nucleotide polymorphisms (SNPs) of the gene encoding interleukin 28B (IL28B) and a sustained virologic response (SVR) to peginterferon (PEG-IFN) plus ribavirin (RBV) therapy in Korean chronic hepatitis C patients. METHODS: This was a retrospective cohort study of 156 patients with chronic hepatitis C virus (HCV) infection who received combination treatment of PEG-IFN plus RBV. Blood samples from these patients were analyzed to identify the IL28B SNPs at rs12979860, rs12980275, rs8099917, and rs8103142. Association analyses were performed to evaluate the relationships between each IL28B SNP and SVRs. RESULTS: Seventy six patients with HCV genotype 1 and 80 with genotype non-1 were enrolled. The frequencies of rs12979860 CC and CT genotypes were 90.4% and 9.6%, respectively; those of rs12980275 AA and AG genotypes were 87.2% and 12.8%, respectively; those of rs8099917 TT and TG genotypes were 92.3% and 7.7%, respectively; and those of rs8103142 TT and CT genotypes were 90.4% and 9.6%, respectively. Among the patients with HCV genotype 1, the SVR rates were 69.7% and 80.0% for rs12979860 CC and CT, respectively (P=0.71). Among the HCV genotype non-1 patients, SVR rates were 88.0% and 100% for rs12979860 CC and CT (P=1.00), respectively. CONCLUSIONS: Genotypes of the IL28B SNP that are known to be favorable were present in most of the Korean patients with chronic hepatitis C in this study. Moreover, the IL28B SNP did not influence the SVR rate in either the HCV genotype 1 or non-1 patients. Therefore, IL28B SNP analysis might be not useful for the initial assessment, prediction of treatment outcomes, or treatment decision-making of Korean chronic hepatitis C patients.
