Pure red-cell aplasia and autoimmune hemolytic anemia in a patient with acute hepatitis A.
10.3350/cmh.2014.20.2.204
- Author:
Hyo Jeong CHANG
1
;
Dong Hyun SINN
;
Sung Gyun CHO
;
Tae Hoon OH
;
Tae Joo JEON
;
Won Chang SHIN
;
Won Choong CHOI
Author Information
1. Department of Internal Medicine, Inje University Sanggye Paik Hospital, Inje University College of Medicine, Seoul, Korea. sinndhn@hanmail.net
- Publication Type:Case Reports ; Review
- Keywords:
Hepatitis A;
Pure red-cell aplasia;
Autoimmune hemolytic anemia
- MeSH:
Acute Disease;
Adult;
Anemia, Hemolytic, Autoimmune/*complications/*diagnosis/drug therapy;
Antineoplastic Agents, Hormonal/therapeutic use;
Bone Marrow/pathology;
Female;
Hepatitis A/*complications/*diagnosis;
Humans;
Male;
Middle Aged;
Prednisolone/therapeutic use;
Red-Cell Aplasia, Pure/*complications/*diagnosis/drug therapy;
Treatment Outcome;
Young Adult
- From:Clinical and Molecular Hepatology
2014;20(2):204-207
- CountryRepublic of Korea
- Language:English
-
Abstract:
Pure red cell aplasia (PRCA) and autoimmune hemolytic anemia (AIHA) have rarely been reported as an extrahepatic manifestation of acute hepatitis A (AHA). We report herein a case of AHA complicated by both PRCA and AIHA. A 49-year-old female with a diagnosis of AHA presented with severe anemia (hemoglobin level, 6.9 g/dL) during her clinical course. A diagnostic workup revealed AIHA and PRCA as the cause of the anemia. The patient was treated with an initial transfusion and corticosteroid therapy. Her anemia and liver function test were completely recovered by 9 months after the initial presentation. We review the clinical features and therapeutic strategies for this rare case of extrahepatic manifestation of AHA.
