Vitamin D deficiency in women with polycystic ovary syndrome.
10.5653/cerm.2014.41.2.80
- Author:
Jin Ju KIM
1
;
Young Min CHOI
;
Soo Jin CHAE
;
Kyu Ri HWANG
;
Sang Ho YOON
;
Min Jeong KIM
;
Sun Mie KIM
;
Seung Yup KU
;
Seok Hyun KIM
;
Jung Gu KIM
Author Information
1. Department of Obstetrics and Gynecology, Healthcare System Gangnam Center, Seoul National University Hospital, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Insulin resistance;
Polycystic ovary syndrome;
Vitamin D
- MeSH:
Body Mass Index;
Female;
Humans;
Insulin Resistance;
Metabolome;
Polycystic Ovary Syndrome*;
Prevalence;
Vitamin D;
Vitamin D Deficiency*
- From:Clinical and Experimental Reproductive Medicine
2014;41(2):80-85
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVE: To investigate: the prevalence of vitamin D deficiency in Korean women with polycystic ovary syndrome (PCOS), and the relationship between vitamin D status and clinical or metabolic features in this group. METHODS: We recruited 38 women with PCOS using the Rotterdam criteria. A total of 109 premenopausal control women were matched with patients based on age and body mass index. Serum 25-hydroxy vitamin D concentrations less than 20 ng/mL were classified as frank vitamin D deficiency. Since vitamin D may play a significant role in metabolic disturbances in women with PCOS, correlations between clinical or metabolic parameters and vitamin D status were analyzed separately in patients and controls. RESULTS: Women with PCOS showed no differences in the level of 25-hydroxy vitamin D (19.6+/-6.6 ng/mL in patients vs. 20.1+/-7.4 ng/mL in controls, respectively, p=0.696) or prevalence of vitamin D deficiency (57.9% in patients vs. 56.5% in controls, respectively, p=0.880). In addition, we did not find any correlations between serum vitamin D level and clinical or metabolic profiles in either PCOS patients or controls. CONCLUSION: Our study found no differences in the absolute level of serum vitamin D between PCOS patients and matched controls. Prevalence of vitamin D deficiency was equally common among both patients and controls. Additionally, we did not find any correlations between serum vitamin D level and clinical or metabolic profiles, suggesting that the role of vitamin D in the pathogenesis of PCOS is not yet clear.
