Adiposity in the Relationship between Serum Vitamin D Level and Insulin Resistance in Middle-Aged and Elderly Korean Adults: The Korea National Health and Nutrition Examination Survey 2008.
- Author:
Ji Hyun KANG
1
;
Sang Soo KIM
;
Seung Su MOON
;
Won Jin KIM
;
Min Jung BAE
;
Bo Gwang CHOI
;
Yun Kyung JEON
;
Bo Hyun KIM
;
Yong Ki KIM
;
In Joo KIM
Author Information
- Publication Type:Original Article
- Keywords: Korea National Health and Nutrition Examination Survey; Vitamin D; Obesity; Insulin resistance
- MeSH: Adiposity; Adult; Aged; Body Mass Index; Fasting; Homeostasis; Humans; Insulin; Insulin Resistance; Korea; Nutrition Surveys; Obesity; Obesity, Abdominal; Subcutaneous Fat; Vitamin D; Vitamins; Waist Circumference
- From:Endocrinology and Metabolism 2013;28(2):96-102
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND: The role of adiposity in the relationship between serum vitamin D levels and insulin resistance has not yet been fully studied. This aim of this study is to clarify the role of adiposity in the relationship between serum vitamin D level and insulin resistance among middle-aged and elderly Korean adults. METHODS: We used data from 2,710 individuals aged > or =50 years based on national data from a representative sample of the fourth Korea National Health and Nutrition Examination Survey IV-2 in 2008. RESULTS: After adjustment for potential confounders, body mass index (BMI) was significantly associated with 25(OH) vitamin D (P=0.008). However, waist circumference was not significantly associated with 25(OH) vitamin D. In the stratified analyses, 25(OH) vitamin D was found to be negatively associated with fasting insulin and homeostasis model assessment estimate of insulin resistance (HOMA-IR) in participants with BMIs > or =25 kg/m2 (P=0.003 for both insulin and HOMR-IR) but was not found to be associated in those with BMIs <23 kg/m2. However, we observed a significant inverse in the association of 25(OH) vitamin D with fasting insulin and HOMA-IR in both the normal (P=0.001 and P<0.001 and the abdominally obese group (P=0.010 and P=0.009) in the stratified analyses according to abdominal obesity. CONCLUSION: Our results support that the idea that endogenously-produced vitamin D might be stored in subcutaneous fat deposits. In addition, the association of vitamin D with insulin resistance in middle-aged and elderly Korean adults was stronger when it was stratified by BMI than when abdominal obesity status.
