Activated Protein C Anticoagulant System Dysfunction and Thrombophilia in Asia.
- Author:
Naotaka HAMASAKI
1
;
Hiroyuki KUMA
;
Hiroko TSUDA
Author Information
- Publication Type:Review ; Research Support, Non-U.S. Gov't
- Keywords: Venous thromboembolism; Activated protein C anticoagulant system; Asian thrombophilia; Deep vein thrombosis; Protein S; Quantitative assay of protein S
- MeSH: Asian Continental Ancestry Group; Blood Coagulation; Blood Proteins/genetics/metabolism; Humans; Protein C/genetics/*metabolism; Protein S/chemistry/genetics/metabolism; Thrombophilia/epidemiology/*etiology; Venous Thrombosis/etiology/genetics
- From:Annals of Laboratory Medicine 2013;33(1):8-13
- CountryRepublic of Korea
- Language:English
- Abstract: Thrombophilia that is common among Caucasians is caused by genetic polymorphisms of coagulation factor V Leiden (R506Q) and prothrombin G20210A. Unlike that in Caucasians, thrombophilia that is common in the Japanese and Chinese involve dysfunction of the activated protein C (APC) anticoagulant system caused by abnormal protein S and protein C molecules. Approximately 50% of Japanese and Chinese individuals who develop venous thrombosis have reduced activities of protein S. The abnormal sites causing the protein S molecule abnormalities are distributed throughout the protein S gene, PROS1. One of the most common abnormalities is protein S Tokushima (K155E), which accounts for about 30% of the protein S molecule abnormalities in the Japanese. Whether APC dysfunction occurs in other Asian countries is an important aspect of mapping thrombophilia among Asians. International surveys using an accurate assay system are needed to determine this.
