Expression Pattern and Prognostic Correlation of BAG - 1 Protein in Breast Cancer.
- Author:
Se Hoon CHO
;
Dae Young LEE
;
Byung Jin KIM
;
Sook Hee HONG
- Publication Type:Original Article
- Keywords:
Breast neoplasm;
BAG-1
- MeSH:
Breast Neoplasms*;
Breast*;
Cytoplasm;
DNA;
Humans;
Ploidies;
Proliferating Cell Nuclear Antigen
- From:Journal of the Korean Cancer Association
2000;32(1):60-67
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: The objective of this study was to understand the expression of BAG-1 in the human breast cancer. MATERIALS AND METHODS: We studied its expression in one hundred and thirteen patients diagnosed with breast cancer in Dong-A university hospital between 1992 and 1996 by performing immunohistochemical staining with BAG-1 monoclonal antibody. RESULTS: Of the 113 breast carcinoma examined, 62.0% were positive for BAG-1 cyto- plasmic expression, 28.0% were positive for nuclear BAG-1 expression and 9.7% were positive for both BAG-1 cytoplasmic and nuclear expression. The higher histologic grade was correlated with the higher cytoplasmic expression (p<0.05). Except for histologic grade, no correlation was observed between BAG-1 expression and conventional prognostic factors such as age, menopausal status, metastatic status of the axillary lymh nodes, cathepsin-D, p53, C-erbB-2, DNA ploidy, S-phase fraction, PCNA (proliferating cell nuclear antigen). CONCLUSION: The high histologic grade was found to correlate with positive BAG-1 cyto- plasmic staining which did not correlate with conventional prognostic factors. Our data indicate that furthermore investigation is warranted to define the role of BAG-1 as an meaningful prognostic factor in patients with newly diagnosed breast cancer.
