A Clinical and Immunohistochemical Study on Gastrointestinal Stromal Tumor.
- Author:
Eun Jung LEE
1
;
Ok Jae LEE
;
Tae Hyo KIM
;
Woon Tae JUNG
Author Information
1. Department of Internal Medicine, Research Institute of Life Science, Gyeongsang National University College of Medicine, Jinju, Korea. ojlee@nongae.gsnu.ac.kr
- Publication Type:Original Article ; English Abstract
- Keywords:
Gastrointestinal stromal tumor;
Gastrointestinal submucosal tumor;
Immunohistochemistry;
Protooncogene protein c-kit
- MeSH:
Adult;
Aged;
Female;
Gastrointestinal Neoplasms/*chemistry/diagnosis/pathology;
Humans;
Immunohistochemistry;
Male;
Middle Aged;
Prognosis;
Proto-Oncogene Proteins c-kit/analysis
- From:The Korean Journal of Gastroenterology
2003;42(3):204-211
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND/AIMS: As the relationship between gastrointestinal stromal tumors (GIST) and interstitial cells of Cajal had become clear, GIST is defined as CD117 positive mesenchymal tumors, and recognized as a new distinct entity among mesenchymal tumors presenting as gastrointestinal submucosal tumors (SMT). To evaluate GISTs in the category of SMTs, we analyzed mesenchymal SMTs immunohistochemically and clinicopathologically. METHODS: Forty-five patients with mesenchymal SMTs, who received surgical or endoscopic resection were retrospectively analyzed for clinical parameters. Immunohistochemical staining for CD117, CD34, NSE, SMA, and S-100 was also performed. RESULTS: Among 45 tumors, 41 (91.1%) expressed CD117 and were diagnosed as GIST. The most frequent location was the gastric body. Except esophageal location (73.3%), GISTs accounted for 100% of SMTs in the gastrointestinal tract. The mixed myoid-neural differentiated type and the spindle cell shape were most common. Metastasis was observed in 5 patients (11%). All of them had tumors larger than 5 cm and died. Their mean survival was 4.6 months. CONCLUSIONS: GIST accounted for majority (91.1%) of SMTs. The presence of metastasis and tumor size at the time of diagnosis indicate poor prognostic factors. Immunohistochemical study is necessary for exact diagnosis of GIST.
