The clinical significance of Interleukin-6 mRNA expression in cervical intraepithelial neoplasia and cervical cancer.
- Author:
Hye Sung MOON
1
;
Eun Ah CHOI
;
Hye Won CHUNG
Author Information
1. Department of Obstetrics & Gynecology, College of Medicine, and Medical Research Center, Korea.
- Publication Type:Original Article
- Keywords:
IL-6;
Cervical cancer;
CIN;
Carcinogenesis
- MeSH:
Carcinogenesis;
Cervical Intraepithelial Neoplasia*;
Cervix Uteri;
Female;
Humans;
Interleukin-6*;
Keratinocytes;
Polymerase Chain Reaction;
Prognosis;
RNA;
RNA, Messenger*;
RNA-Directed DNA Polymerase;
Uterine Cervical Neoplasms*
- From:Korean Journal of Obstetrics and Gynecology
2002;45(4):659-665
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVES: Interleukin-6 is a pleiotrophic cytokine that is not only a mediator in major immunologic reactions but also a growth factor of keratinocytes. We studied IL-6 mRNA expression in cervical cancer, CIN and normal cervix. And we questioned whether its expression is related to cervical carcinogenesis and other prognostic factors. METHODS: The normal cervical and cervical cancer tissues were taken from healthy women (n=16), and the patients with CIN (n=36) and cervical cancer (n=36). The IL-6 mRNA expression was examined by quantitative competitive PCR after polymerase chain reaction amplification of reverse transcriptase copies of RNA transcripts (RT-PCR). RESULTS: There was no statistically different among cervical cancer, CIN and normal cervix (p>0.05). The IL-6 mRNA expression was not different according to the grades of CIN. Its expression was not correlated with the stage of cervical cancer, size of tumor, and histopathologic type (p>0.05). CONCLUSION: These results suggested that IL-6 mRNA expression might not be associated with the cervical carcinogenesis and prognosis of cervical cancer.
