Recanalization Rate and its Associated Factors after Intravenous Tissue Plasminogen Activator Thrombolysis for Acute Major Cerebral Arterial Occlusion.
- Author:
Won Ki YOON
1
;
Young Woo KIM
;
Sung Rhim KIM
;
Seung Hoon YOU
;
Ik Sung PARK
;
Sang Don KIM
;
Min Woo BAIK
Author Information
1. Department of Neurosurgery, Holy Family Hospital, the Catholic University of Korea, Korea.
- Publication Type:Original Article
- Keywords:
Atrial fibrillation;
Cerebral arterial occlusion;
Recanalization;
Tissue plasminogen activator
- MeSH:
Administration, Intravenous;
Atrial Fibrillation;
Classification;
Humans;
Infarction;
Mortality;
Myocardial Infarction;
Stroke;
Tissue Plasminogen Activator*
- From:Korean Journal of Cerebrovascular Surgery
2007;9(4):265-270
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: To investigate the recanalization rate after intravenous administration of recombinant tissue plasminogen activator (IV-tPA) for acute major arterial occlusion of the anterior cerebral circulation and to investigate the relationship between atrial fibrillation and recanalization. METHODS: From April 2005 to April 2006, 16 patients with acute major arterial occlusion of the anterior cerebral circulation were treated with IV-tPA. Recanalization was classified as good (as compared with an unoccluded contralateral vessel; thrombolysis in myocardial infarction (TIMI) classification grade II and III) and poor (TIMI grade 0 and I). The clinical and radiological parameters associated with recanalization were analyzed. The clinical outcomes were evaluated by use of the National Institute of Health Stroke Scale (NIHSS) at 3 months after treatment. RESULTS: Of all of the 16 patients, 11 patients (68.8%) showed good recanalization. Among these 11 patients, nine patients survived (81.8%). However, only one patient survived (20%, p = 0.036) of the other five patients who showed poor recanalization. The pretreatment NIHSS score and atrial fibrillation were significantly correlated with the recanalization rate. Atrial fibrillation was found in 8 of 16 patients (50.0%) as the cause of the cerebral embolic infarction. Among the patients with atrial fibrillation only three patients showed good recanalization (37.5%); patients without atrial fibrillation showed good recanalization (100%, p = 0.026). CONCLUSIONS: I.-tPA appears to be effective and safe as a recanalization method for acute major cerebral arterial occlusion in patients that do not have atrial fibrillation. Good recanalization was associated with a good clinical result. Atrial fibrillation is a significant associated factor of poor recanalization and high mortality.
