Umbilical Cord Blood Matrix Metalloproteinase-9 Levels are associated with Funisitis.
10.14734/kjp.2015.26.1.58
- Author:
Soon Sup SHIM
1
;
Hye Sim KANG
;
Young Hee MAENG
;
Young Don KIM
Author Information
1. Department of Obstetrics and Gynecology, Jeju National University School of Medicine, Jeju, Korea.
- Publication Type:Original Article
- Keywords:
Umbilical cord blood;
Chorioamnionitis;
Funisitis;
Bronchopulmonary dysplasia;
Tumor necrosis factor-alpha;
Matrix metalloproteinase;
Intercellular adhesion molecule
- MeSH:
Bronchopulmonary Dysplasia;
Chorioamnionitis*;
Female;
Fetal Blood*;
Humans;
Immunoassay;
Infant, Newborn;
Infant, Premature;
Inflammation;
Intercellular Adhesion Molecule-1;
Matrix Metalloproteinase 8;
Matrix Metalloproteinase 9*;
Placenta;
Pregnancy;
Pregnant Women;
ROC Curve;
Tumor Necrosis Factor-alpha
- From:Korean Journal of Perinatology
2015;26(1):58-66
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: Intrauterine inflammation (IUI) is a leading cause of preterm delivery. Although matrix metalloproteinase-8 (MMP-8) and intercellular adhesion molecule-1 (ICAM-1) are known to be related with IUI, it has not been fully elucidated whether MMP-9 or ICAM-3 is associated with IUI. We performed this study to determine whether the levels of tumor necrosis factor-alpha (TNF-alpha), MMP-9 and ICAM-3 in umbilical cord blood of preterm infants are associated with chorioamnionitis, funisitis or bronchopulmonary dysplasia. METHODS: Eighty-two pairs of pregnant women and their preterm newborns <35 weeks gestation were enrolled. Levels of TNF-alpha, MMP-9 and ICAM-3 in umbilical cord blood were measured using immunoassays and compared with results of histological examination of placenta and clinical data of the study participants. RESULTS: The level of MMP-9 in umbilical cord blood was significantly associated with the presence of funisitis (P =0.007). The level of TNF-alpha in umbilical cord blood was significantly associated with the development of bronchopulmonary dysplasia (P =0.030). However, presence of chorioamnionitis or funisitis was not associated with development of bronchopulmonary dysplasia. With the establishment of receiver operating characteristic (ROC) curve, the best cut-off value for umbilical blood MMP-9 was 99.42 pg/mL in identification of funisitis. The area under a constructed ROC curve for prediction of funisitis was 0.847 (standard error, 0.112; 95% confidence interval, 0.750-0.917). CONCLUSION: Measurement of MMP-9 concentration in umbilical cord blood may be an alternative way to predict whether a preterm infant has been exposed to IUI. Further study with larger numbers of subjects will be necessary to elucidate the association between the presence of IUI and neonatal adverse outcome.
