Clinical Outcomes in Patients with Intermediate Coronary Stenoses: MINIATURE Investigators (Korea MultIceNter TrIal on Long-Term Clinical Outcome According to the Plaque Burden and Treatment Strategy in Lesions with MinimUm Lumen ARea lEss Than 4 mm2 Usin.
10.4070/kcj.2014.44.3.148
- Author:
Young Joon HONG
;
Yun Ha CHOI
;
Soo Young PARK
;
Chang Wook NAM
;
Jang Hyun CHO
;
Won Yu KANG
;
Sang Rok LEE
;
Sung Yun LEE
;
Sang Wook KIM
;
Sang Yeob LIM
;
Kyung Ho YUN
;
Jung Sun KIM
;
Jin Won KIM
;
Woong Chol KANG
;
Ki Seok KIM
;
Jin Ho CHOI
;
Joong Wha CHUNG
;
Soo Joong KIM
;
Youngkeun AHN
;
Myung Ho JEONG
- Publication Type:Original Article
- Keywords:
Coronary artery disease;
Atherosclerotic plaque;
Intravascular ultrasonography
- MeSH:
Constriction, Pathologic;
Coronary Artery Disease;
Coronary Stenosis*;
Diabetes Mellitus;
Follow-Up Studies;
Humans;
Incidence;
Myocardial Infarction;
Percutaneous Coronary Intervention;
Plaque, Atherosclerotic;
Prospective Studies;
Research Personnel*;
Stents;
Ultrasonography;
Ultrasonography, Interventional
- From:Korean Circulation Journal
2014;44(3):148-155
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND AND OBJECTIVES: We evaluated the two-year clinical outcomes in patients with angiographically intermediate lesions according to the plaque burden and treatment strategy. SUBJECTS AND METHODS: We prospectively enrolled patients with angiographically intermediate lesions (diameter stenosis 30-70%) with an intravascular ultrasound (IVUS) minimum lumen area (MLA) <4 mm2 with 50-70% plaque burden of 16 Korean percutaneous coronary intervention centers. Patients were divided into medical therapy group (n=85) and zotarolimus-eluting stent group (ZES; Resolute) group (n=74). We evaluated the incidences of two-year major adverse cardiovascular events (MACE). RESULTS: A two-year clinical follow-up was completed in 143 patients and MACE occurred in 12 patients. There were no significant differences in the incidences of death (1.3% vs. 3.0%, p=0.471), target vessel-related non-fatal myocardial infarction (0.0% vs. 0.0%, p=1.000) and target vessel revascularizations (7.8% vs. 4.5%, p=0.425) between medical and ZES groups. Independent predictors of two-year MACE included acute myocardial infarction {odds ratio (OR)=2.87; 95% confidence interval (CI) 1.43-6.12, p=0.014}, diabetes mellitus (OR=2.46; 95% CI 1.24-5.56, p=0.028) and non-statin therapy (OR=2.32; 95% CI 1.18-5.24, p=0.034). CONCLUSION: Medical therapy shows comparable results with ZES, and myocardial infarction, diabetes mellitus and non-statin therapy were associated with the occurrence of two-year MACE in patients with intermediate lesion with IVUS MLA <4 mm2 with 50-70% of plaque burden.
