The Clinical Outcome of Protocol R-11 Chemotherapy in Patients with Late Relapse of Childhood Acute Lymphoblastic Leukemia.
- Author:
Baek Nam KIM
1
;
Kyung Jae LEE
;
Chuhl Joo LYU
;
Chang Hyun YANG
;
Kir Young KIM
;
Hwang Min KIM
Author Information
1. Department of Pediatrics, Yonsei University College of Medicine, Seoul, Korea. yangch22@yumc.yonsei.ac.kr
- Publication Type:Original Article
- Keywords:
Acute lymphoblastic leukemia;
Late relapse;
Rotational combination chemotherapy
- MeSH:
Child;
Disease-Free Survival;
Drug Therapy*;
Drug Therapy, Combination;
Gangwon-do;
Humans;
Leukopenia;
Precursor Cell Lymphoblastic Leukemia-Lymphoma*;
Recurrence*;
Remission Induction;
Thrombocytopenia
- From:Korean Journal of Pediatric Hematology-Oncology
2001;8(2):197-205
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: This study is to see chemotherapeutic results followed by Rotational Combination Chemotherapy (R-11 protocol) treatment for the patients with late relapse of childhood ALL six months after the completion of chemotherapy. METHODS: The subjects of study were the 13 children who had been diagnosed as ALL at the Severance Hospital and the Wonju Christian Hospital and completed the chemotherapy. They, however, diagnosed a late relapse of ALL between December, 1996 and December, 2001. After that, they were given an chemotherapy with R-11 protocol. RESULTS: The average age of the 13 patients was 11.8 ( 2.8) years old at relapse. They showed the complete remission (8 patients, 61%), partial remission (4, 31%), and induction failure (1, 8%). The total remission ratio was 92%. Four year Event Free Survival (EFS) after the second remission was 61.5%. They also showed acute toxicity during remission induction with severe than grade III according to the WHO criteria. The leukopenia and thrombocytopenia (hematologic toxicity) were seen at 11 cases (84%) and 9 cases (69%) respectively, and hepatotoxicity (non-hematologic toxicity) was shown at 6 cases (46%). There are also chronic toxicity, one case developed leukomalacia, and 6 cases did various symptoms of infections. CONCLUSION: There is no optimal chemotherapeutic protocol for late relapse of childhood ALL, and the treatment with R-11 protocol is worth a trial.
