CD68 Positive Histiocytic Necrotizing Lymphadenitis.
- Author:
Jin A PARK
1
;
Euk PARK
;
Sung Jun JANG
;
Set Byul PARK
;
Heung Sik KIM
;
Hyun Chang JU
;
Sang Sook LEE
Author Information
1. Department of Pediatrics, Keimyung University College of Medicine, Daegu, Korea. kimhs@dsmc.or.kr
- Publication Type:Case Report
- Keywords:
Cervical lymphadenopathy;
CD68;
Histiocytic necrotizing lymphadenitis;
Kikuchi's disease
- MeSH:
Adolescent;
Anti-Bacterial Agents;
Biopsy;
Child;
Female;
Fever;
Histiocytes;
Histiocytic Necrotizing Lymphadenitis*;
Humans;
Leukopenia;
Lymph Nodes;
Lymphadenitis;
Lymphatic Diseases;
Male;
Nausea;
Sweat;
T-Lymphocytes;
Vomiting;
Weight Loss
- From:Korean Journal of Pediatric Hematology-Oncology
2001;8(2):349-354
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Histiocytic necrotizing lymphadenitis (Kikuchi's disease) is a cause of benign lymphadenitis, most commonly affecting young women and usually presenting as a painless or painful cervical lymphadenopathy sometimes associated with fever and leukopenia. Less frequent symptoms include weight loss, nausea, vomiting, and night sweats. We experienced two cases of histiocytic necrotizing lymphadenitis in an 11-year-old boy and a 13-year-old boy. They presented cervical lymphadenopathy with fever in one patient and without fever in the other patient. Lymph node enlargement did not respond to antibiotics. We performed surgical biopsy of cervical lymph node which was consistent with histiocytic necrotizing lymphadenitis. In one patient CD8 T cells and CD68 histiocytes were shown in immunohistochemical stain. So we report two cases of histiocytic necrotizing lymphadenitis with brief review of the related literature.
