An Association Study between the Dopamine D5 Receptor Gene and Korean Schizophrenia.
- Author:
Ju Yeon CHO
1
;
Joon Mo KIM
;
Min Su LEE
;
Doo Byung PARK
Author Information
1. Department of Psychiatry, College of Medicine, Chung-Ang University, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Schizophrenia;
Association study;
Dopamine D5 receptor gene
- MeSH:
Alleles;
Dopamine*;
Genetic Loci;
Genotype;
Humans;
Korea;
Polymerase Chain Reaction;
Receptors, Dopamine D5*;
Schizophrenia*
- From:Journal of Korean Neuropsychiatric Association
1999;38(2):389-398
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: This study was performed to define the genetic relationship between the micro-satellite (CT/GT/GA)n polymorphism for the dopamine D5 receptor gene and schizophrenia. An association study in 100 schizophrenic patients and 100 normal controls of Korea was made by means of using polymerase chain reaction. RESULTS: The microsatellite(D5(CT/GT/GA)n) had 11 alleles. There was a significant difference in the allele distribution between schizophrenia and normal controls(p<0.05). In schizophrenic patients, the frequency of allele A10 was decreased. As to the genotype distribution, there was no difference in both groups. CONCLUSIONS: This finding suggests that dopamine D5 gene is likely to be related to the development of schizophrenia in Korea but with only this result, we cannot come to the conclusion that this genetic locus is the genetic determinant of schizophrenia. Further studies of dopamine D5 receptor genetic locus that can confirm this result should be made.
