Symptom Aggravation in an Elderly Schizophrenic due to Lorazepam Discontinuation of Long-term Use of Minimal Dosage: A Case Report.
- Author:
Kwang Iel KIM
1
;
Ki Jun KIM
Author Information
1. Department of Neuropsychiatry, College of Medicine & The Metnal Health Research Institute, Hanyang University, Seoul, Korea.
- Publication Type:Case Report
- Keywords:
Lorazepam;
Withdrawal psychosis;
Withdrawal symptom;
Schizophrenia
- MeSH:
Aged*;
Benzodiazepines;
Chlorpromazine;
Humans;
Lorazepam*;
Middle Aged;
Psychotic Disorders;
Schizophrenia;
Substance Withdrawal Syndrome
- From:Journal of Korean Neuropsychiatric Association
1999;38(2):419-423
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Withdrawal psychosis following long-term administration of benzodiazepine is relatively unclear and has rarely reported. Especially, there are few reports of lorazepam withdrawal characterized by psychotic aggravation in schizophrenia. We report a 64 years old chronic schizophreinc case who developed symptom aggravation and paroxysmal attack of severe psychotic symptom, following discontinuation of 1mg lorazepam, which has been used in combination with 100mg chlorpromazine for 13 years. It was suggested that long-term combination therapy with benzodiazepines in schizophrenia was strongly discouraged even if its dosage is minimal.
