Clinical Significance of Lymph Node Micrometastasis in Patients with Dukes' B Colorectal Cancer.
- Author:
Hyo Won LEE
1
;
Yong Seog JANG
Author Information
1. Department of Surgery, College of Medicine, Soonchunhyang University Hospital, Seoul, Korea. ysjang57@hosp.sch.ac.kr
- Publication Type:Original Article
- Keywords:
Colorectal neoplasms;
Dukes' B;
Lymphatic metastasis;
Survival rate;
Immunohistochemistry
- MeSH:
Colorectal Neoplasms*;
Humans;
Immunohistochemistry;
Lymph Nodes*;
Lymphatic Metastasis;
Neoplasm Metastasis;
Neoplasm Micrometastasis*;
Neoplasm Staging;
Retrospective Studies;
Survival Rate
- From:Journal of the Korean Society of Coloproctology
2004;20(1):57-63
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: This study aimed to provide immunohistochemical evidence of micrometastasis in patients with node-negative Dukes' B colorectal cancer and to evaluate the clinical implications, including prognostic significance, of lymphatic metastasis. METHODS: A retrospective study of 90 patients who underwent a curative operation due to colorectal neoplasms from 1996 to 2001 was performed. Two consecutive sections of lymph nodes were prepared: one for ordinary hematoxylin-eosin staining, and the other for immunohistochemistry with pancytokeratine antibody. All clinical factors, including survival rate, were compared between patients with and without lymph-node metastasis. The mean follow- up period was 36.1 months. RESULTS: Micrometastasis was confirmed in 115 nodes (7.9%) from 32 patients (35.6%). No correlations were observed between micrometastases and prognostic factors, including survival rate, except for lymphatic invasion and postoperative TNM staging. Twenty-six of the 32 (81.3%) patients with micrometastases belonged to stage T3N0M0 (P<0.003). CONCLUSIONS: The immunohistochemical assay may be a useful way to identify micrometastasis in patients with Dukes' B colorectal neoplasms, but we were not able to demonstrate the prognostic significance of micrometastasis.
