Significance of p53, cyclin D1 and c-myc Expressions in Thyroid Tumors.
- Author:
Zhuhu LI
1
;
Ho Jong JEON
;
Mi Ja LEE
Author Information
1. Department of Pathology, College of Medicine, Chosun University, Gwangju, Korea. mjblee@mail.chosun.ac.kr
- Publication Type:Original Article
- Keywords:
Thyroid Tumor;
p53;
cyclin D1;
c-myc
- MeSH:
Adenoma;
Carcinogenesis;
Carcinoma;
Carcinoma, Papillary;
Cell Cycle;
Cyclin D1*;
Cyclins*;
Hyperplasia;
Immunohistochemistry;
Lymph Nodes;
Neoplasm Metastasis;
Thyroid Gland*
- From:Korean Journal of Pathology
2004;38(1):29-34
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: The G1/S phase proteins of the cell cycle play critical roles in tumorigenesis and tumor progression. Our aim was to investigate the significance of p53, cyclin D1 and c-myc expressions in thyroid tumors. METHODS: The expressions of these proteins were examined in 217 cases of thyroid tumors and tissues using immunohistochemistry. The results were correlated with lymph node metastasis. RESULTS: p53 expression was seen in 75.5, 47.5, 66.7, and 50% of papillary carcinomas (PC), follicular carcinomas (FC), undifferentiated carcinomas (UC) and follicular adenomas (FA), respectively. There was a significant difference between these expressions in these tumors and the results in nodular hyperplasia (NH) and normal tissues. Cyclin D1 expression was noted in 80.0, 68.4, 66.7, 61.1 and 79.5% of PC, FC, UC, FA and NH, respectively. c-myc expression was seen in 80.0, 94.2, 66.7, 66.7 and 52.3% of PC, FC, UC, FA and NH, respectively. There was a significant association between the expressions in these tumors and the results in normal tissues. The expressions of p53, cyclin D1 and c-myc were not correlated with lymph node metastasis. CONCLUSIONS: These findings suggest the expressions of p53, cyclin D1 and c-myc may act in the early stage, and participates in tumorigenesis and promoting cell growth.
