Squamous Cell Carcinoma Developed in Nevus Sebaceus: A Case Report.
- Author:
Hyun Joo CHOI
1
;
Jinyoung YOO
;
Lee So MAENG
;
Seok Jin KANG
;
Chang Suk KANG
Author Information
1. Department of Clinical Pathology, College of Medicine, The Catholic University of Korea, Seoul, Korea.Jinyyoo@catholic.ac.kr
- Publication Type:Case Report
- Keywords:
Nevus Sebaceus;
Squamous Cell Carcinoma
- MeSH:
Aged, 80 and over;
Carcinoma, Squamous Cell*;
Cheek;
Diagnosis;
Epidermis;
Female;
Germ Cells;
Humans;
Nevus*;
Skin
- From:Korean Journal of Pathology
2004;38(1):60-63
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
We report a case of squamous cell carcinoma developed within the nevus sebaceus (NS) and review the literature. An 82-year-old woman presented with a 3-month history of pain within the lifelong skin lesion on her right cheek. Examination revealed a 1.0 x 1.0 cm poorly marginated, slightly raised yellow-brown nodule. Microscopically, the skin nodule revealed the typical findings of NS. Squamous cell carcinoma developed contiguously within the keratin-filled infundibulocyst of NS disconnected from the epidermis. We suggest that squamous cell carcinoma is derived from the embryonal stratum germinativum de-differentiated from the primary epithelial germ cells in the infundibulocyst of NS. Most secondary carcinomas associated with NS grow slowly over a period of years. In contrast, squamous cell carcinoma developed in NS often grow rapidly with aggressive behavior. Thus, the accurate pathologic diagnosis is necessary.
