Korean Patients Undergoing Deceased Donor Liver Transplantation for Alcoholic Liver Disease Have Non-Inferior Survival Outcomes than for Hepatitis B Virus: a Real-World Experience without Minimum Abstinence before Transplantation.
10.3346/jkms.2017.32.6.919
- Author:
Suk Kyun HONG
1
;
Nam Joon YI
;
Hyo Sin KIM
;
Sung Woo AHN
;
Kyung Chul YOON
;
Hyeyoung KIM
;
Kwang Woong LEE
;
Kyung Suk SUH
Author Information
1. Department of Surgery, Seoul National University College of Medicine, Seoul, Korea. gsleenj@gmail.com
- Publication Type:Original Article
- Keywords:
Alcohol;
Liver Cirrhosis;
Liver Transplantation;
Outcome
- MeSH:
Alcoholics*;
Asian Continental Ancestry Group;
gamma-Glutamyltransferase;
Hepatitis B virus*;
Hepatitis B*;
Hepatitis*;
Humans;
Liver Cirrhosis;
Liver Diseases, Alcoholic*;
Liver Transplantation*;
Liver*;
Living Donors;
Multivariate Analysis;
Retrospective Studies;
Seoul;
Social Control, Formal;
Survival Rate;
Tissue Donors*
- From:Journal of Korean Medical Science
2017;32(6):919-925
- CountryRepublic of Korea
- Language:English
-
Abstract:
Few studies have compared outcomes in patients undergoing liver transplantation (LT) for hepatitis B virus (HBV) and alcoholic liver disease (ALD) in Asian countries in which living donor LT (LDLT) is dominant, where HBV is endemic and where there are no strict regulations on pre-transplant abstinence for ALD. This study compared post-LT outcomes of deceased donor LT (DDLT) in patients with ALD and HBV. Data from 220 patients who underwent primary DDLT at Seoul National University Hospital from January 2010 to December 2014, including 107 with HBV and 38 with ALD, were retrospectively analyzed. Seventy-four patients (69.2%) in the HBV group and 30 (78.9%) in the ALD group had United Network for Organ Sharing (UNOS) status 2A (P = 0.250). There were no significant differences in their 1-year (90.7% vs. 92.1%) and 3-year (82.1% vs. 82.3%) overall survival rates (P = 1.000). Multivariate analysis showed that high serum gamma glutamyltransferase concentration (≥ 70 IU/L) was independently prognostic of 1-year post-LT overall survival. Survival outcomes following DDLT were similar in Korean patients with ALD and HBV, even in the absence of strict pre-transplant abstinence from alcohol as a selection criterion.
