Successful Treatment of Infantile Fibrosarcoma Spinal Metastasis by Chemotherapy and Stereotactic Hypofractionated Radiotherapy.
10.3340/jkns.2013.54.6.528
- Author:
Cheng Hsiang LO
1
;
Shin Nan CHENG
;
Kuen Tze LIN
;
Yee Min JEN
Author Information
1. Department of Radiation Oncology, Tri-Service General Hospital, National Defense Medical Center, Taiwan, ROC. yeeminjen@gmail.com
- Publication Type:Case Report
- Keywords:
Cyberknife(R);
Hypofractionated radiotherapy;
Infantile fibrosarcoma;
Spinal metastasis
- MeSH:
Drug Therapy*;
Fibrosarcoma*;
Humans;
Infant;
Leg;
Lumbar Vertebrae;
Male;
Neoplasm Metastasis*;
Positron-Emission Tomography;
Radiotherapy*;
Recurrence
- From:Journal of Korean Neurosurgical Society
2013;54(6):528-531
- CountryRepublic of Korea
- Language:English
-
Abstract:
We report a case of infantile fibrosarcoma in an 8-month-old boy manifested as a right-sided lower leg mass. Repeated local recurrence and distant metastasis were noted during the following three-year period. Whole body fluoro-deoxyglucose positron emission tomography scan revealed an asymptomatic metastasis involving the fourth lumbar vertebrae. The patient received chemotherapy (VAC regimen) with Cyberknife(R) stereotactic hypofractionated radiotherapy (26 Gy; 4 fractions). This treatment reduced tumor size by 23% without acute radiation toxicity even after 33 months. This case suggests that combining chemotherapy and this form of radiotherapy may be safe and effective against childhood spinal metastasis.
