The Hemodynamic Effects of Ropivacaine Infiltration at the Skull-pin Insertion Sites and the Incision Site in Craniotomy.
10.4097/kjae.2003.45.2.194
- Author:
Jong Cheol CHOI
1
;
Chang Young JEONG
;
Sang Hyun KWAK
;
Myung Ha YOON
Author Information
1. Department of Anesthesiology and Pain Medicine, Chonnam National University Medical School, Gwangju, Korea. mhyoon@chonnam.ac.kr
- Publication Type:Original Article ; Randomized Controlled Trial
- Keywords:
craniotomy;
hemodynamics;
infiltration;
ropivacaine
- MeSH:
Anesthesia, General;
Blood Pressure;
Craniotomy*;
Heart Rate;
Hemodynamics*;
Humans;
Neurosurgery;
Skin
- From:Korean Journal of Anesthesiology
2003;45(2):194-199
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Several drugs have been used to reduce the hemodynamic responses evoked by skull-pin head-holder application and skin incision in neurosurgery. This study evaluated the effects of ropivacaine infiltration on hemodynamics followed by the skull-pin head-holder application and the skin incision. METHODS: Sixty-six patients who had been scheduled for neurosurgery under general anesthesia were randomly divided into five groups. Saline or different concentrations of ropivacaine (0.1, 0.2, 0.5, 0.75%) were infiltrated into skull-pin head-holder insertion sites and the skin incision site. Systolic and diastolic blood pressure, and heart rate were measured just before skull-pin head-holder application and 30 sec, 1 min, 3 min, and 5 min after skull-pin head-holder application and skin incision. Changes in hemodynamics were compared. RESULTS: The systolic blood pressure (SBP) significantly increased on 30 sec and 1 min after skull-pin head-holder application, and on 30 sec, 1 min, 3 min, and 5 min after skin incision in the saline group and in the 0.1% ropivacaine group, respectively. Increased SBP was attenuated by 0.75% ropivacaine over the entire observation period. Increased diastolic blood pressure was reduced by 0.5% and 0.75% of ropivacaine at all times. The heart rate significantly increased on 30 sec and 1 min after skull-pin head-holder application in the saline group and in the 0.1% group. This increased heart rate was suppressed by 0.2%, 0.5%, and 0.75% ropivacaine. CONCLUSIONS: These results indicate that ropivacaine attenuates the hemodynamic responses evoked by skull-pin head-holder application or skin incision in craniotomy. Ropivacaine was most active at 0.75%.
