Clinical Effects of Various Antiinflammatory Therapies in Dry Eye Syndrome.
- Author:
Jun HER
1
;
Sun Im YU
;
Sung Gwan SEO
Author Information
1. Department of Ophthalmology Pusan Paik Hospital Inje University College of Medicine, Pusan, Korea. hereye@inje.ac.kr
- Publication Type:Original Article
- Keywords:
Antiinflammatory theraphy;
Autologous serum;
Corticosteroid;
Cyclosporin A;
Dry eye syndrome
- MeSH:
Cyclosporine;
Dry Eye Syndromes*;
Humans;
Ophthalmic Solutions;
Tears
- From:Journal of the Korean Ophthalmological Society
2006;47(12):1901-1910
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: To evaluate the therapeutic effect of cyclosporin A, corticosteroid, autologous serum in patients with severe dry eye syndrome. METHODS: Patients (72 eyes) with severe dry eye syndrome were classified into four groups were treated for 3 months. Each group was treated with 0.05% cyclosporin A, 1% rimexolone, 20% autologous serum, and artificial tears. Before and after treatment (2, 4, 8, 12 weeks), Ocular Surface Disease Index (OSDI), tear film break-up time (BUT), Schirmer test, corneal sensitivity, and lissamine green staining score were measured. RESULTS: After treatment, OSDI, tear film BUT, Schirmer test, corneal sensitivity, and the lissamine green staining score were improved in groups using cyclosporin A, autologous serum and corticosteroid(p<0.05), but clinical effects did not improve in the group using artificial tears except for corneal sensitivity (p>0.05). CONCLUSIONS: Antiinflammatory theraphy is more effective than the conventional symptomatic theraphy in patients with severe dry eye syndrome.
