A Transfer of Silver Nanoparticles from Pregnant Rat to Offspring.
- Author:
Yeonjin LEE
1
;
Jonghye CHOI
;
Pilje KIM
;
Kyunghee CHOI
;
Suhyon KIM
;
Woochan SHON
;
Kwangsik PARK
Author Information
1. College of Pharmacy, Dongduk Women's University, Seoul 136-714, Korea. kspark@dongduk.ac.kr
- Publication Type:Brief Communication
- Keywords:
Silver nanoparticles;
Pregnant rats;
Placenta transfer;
Accumulation in pups
- MeSH:
Animals;
Brain;
Electrons;
Fetus;
Kidney;
Liver;
Lung;
Nanoparticles;
Parturition;
Placenta;
Rats;
Silver
- From:Toxicological Research
2012;28(3):139-141
- CountryRepublic of Korea
- Language:English
-
Abstract:
Silver nanoparticles (size: 7.9 +/- 0.95 nm, dosage: 250 mg/kg) were orally administered to pregnant rats. At 4 days after parturition, four pups were randomly selected (one pup from one dam) and silver level in liver, kidney, lung and brain was determined by ICP-MS and electron microscope. As results, silver nanoparticles highly accumulated in the tissues of the pups. Silver level in the treated group was 132.4 +/- 43.9 ng/g in the kidney (12.3 fold compared to control group), 37.3 +/- 11.3 ng/g in the liver (7.9 fold), 42.0 +/- 8.6 ng/g in the lung (5.9 fold), and 31.1 +/- 4.3 ng/g in the brain (5.4 fold). This result suggested that the possible transfer of silver nanoparticles from pregnant dams to the fetus through mainly placenta.
