Distribution Characteristics of Hepatitis B Serological Markers in Hospitalized Children and Adolescents in Zhejiang, China between 2006 and 2010.
- Author:
Xuejun CHEN
1
;
Yuefang SHEN
;
Wenqing XIANG
Author Information
1. Department of Clinical Laboratory, The Children's Hospital of Zhejiang University School of Medicine, Hangzhou, China.
- Publication Type:Original Article
- Keywords:
Hepatitis B antibodies;
Chemiluminescent measurements;
Immunoassay;
Epidemiologic studies;
Children
- MeSH:
Adolescent;
Child;
Child, Hospitalized;
China;
Epidemiologic Studies;
Hepatitis;
Hepatitis B;
Hepatitis B Antibodies;
Hepatitis B Surface Antigens;
Hepatitis B virus;
Humans;
Immunoassay;
Luminescent Measurements;
Organothiophosphorus Compounds;
Vaccination
- From:Gut and Liver
2011;5(2):210-216
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND/AIMS: To investigate serological patterns of hepatitis B based on electrochemiluminescent immunoassays and the distribution characteristics of these patterns in hospitalized children and adolescents in Zhejiang, China between 2006 and 2010. METHODS: Five serological markers, including hepatitis B surface antigen (HBsAg), hepatitis B e antigen (HBeAg), antibody to hepatitis B surface antigen (anti-HBs), antibody to hepatitis B e antigen (anti-HBe), and antibody to hepatitis B c antigen (anti-HBc), were chosen as a routine panel to monitor hepatitis B virus (HBV) infection and vaccination efficacy. A total of 33,187 children (21,187 boys and 12,000 girls) were selected using the following exclusion criteria: a previous diagnosis of hepatitis, age >16 years or an address outside of Zhejiang. RESULTS: The average HBV vaccination coverage rates among 20,766 boys and 11,782 girls were 98.62% and 98.68%, respectively. Seventeen serological patterns of hepatitis B were found, and the dominant pattern was 'anti-HBs (+) alone' (62.03%) followed by 'negative pattern' (23.46%). The rates of the other 15 patterns ranged from 8.14% to 0.003%. Of 236 HBsAg-positive patients, the overall rate of seropositivity was 0.71%. The anti-HBs levels were grouped into 3 ranges (10-100 mIU/mL, 100-1,000 mIU/mL, and >1,000 mIU/mL) for all anti-HBs-positive children (36.08%, 43.43%, and 20.49%, respectively). CONCLUSIONS: A low HBsAg carrier rate and a relatively high anti-HBs positive rate are present in hospitalized children and adolescents in Zhejiang. The distribution of serological patterns is associated with age but is mostly independent of gender.
