Analysis of nm23 expression as a prognostic parameter in renal cell carcinoma.
10.3346/jkms.1995.10.4.258
- Author:
Dong Soo PARK
1
;
Nam Hoon CHO
;
Young Tae LEE
;
Chanil PARK
;
Jin Moo LEE
Author Information
1. Department of Urology, Yonsei University College of Medicine, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Renal cell carcinoma;
nm23;
Immunohistochemistry;
Prognostic parameter
- MeSH:
Adult;
Aged;
Carcinoma, Renal Cell/*enzymology/mortality/pathology;
Disease-Free Survival;
Female;
Human;
Kidney Neoplasms/*enzymology/mortality/pathology;
Male;
Middle Age;
Neoplasm Staging;
Nucleoside-Diphosphate Kinase/*analysis;
Prognosis;
Transcription Factors/*analysis
- From:Journal of Korean Medical Science
1995;10(4):258-262
- CountryRepublic of Korea
- Language:English
-
Abstract:
To identify the clinicopathological events including nm23 expression that underlies progression in renal cell carcinoma, a retrospective analysis of patients with renal cell carcinoma was performed. Ninety-eight cases of radical nephrectomies with extensive regional or para-aortic lymph node dissection were assessed for clinicopathological variables, and eighty-five cases underwent nm23/NDPK-A protein immunohistochemical staining. Significant parameters in survival were tumor size, histologic pattern, Fuhrman's nuclear grade, pathologic T(pT) stage, pathologic N stage, M stage, tumor thrombi, location of metastasis, and nm23 staining intensity. To assess the relationship with survival, the tumors with low and high nm23 expressions were compared. The fifty-nine patients with a high staining intensity had a significantly worse survival than did the twenty-six with a low staining intensity (p = 0.0015). Additionally nm23 staining intensity was correlated with tumor size, Fuhrman's nuclear grade, pT, and distant metastasis. Therefore, the immunostaining intensity of nm23 protein could be used as a prognostic parameter with an inverse correlation.
