Correlation between inflammatory markers and the progression of atherosclerosis in patients with coronary artery disease.
- Author:
Jun Ho BAE
1
;
Jong Seon PARK
;
Geu Ru HONG
;
Dong Gu SHIN
;
Young Jo KIM
;
Bong Sup SHIM
Author Information
1. Department of Internal Medicine, Dongguk University College of Medicine, Gyeongju, Korea.
- Publication Type:Original Article
- Keywords:
Cell adhesion molecules;
Inflammation;
Coronary disease
- MeSH:
Angiography;
Atherosclerosis;
Cardiovascular Diseases;
Cell Adhesion Molecules;
Constriction, Pathologic;
Coronary Artery Disease;
Coronary Disease;
Coronary Vessels;
Diabetes Mellitus;
Follow-Up Studies;
Glycosaminoglycans;
Humans;
Inflammation;
Logistic Models;
Percutaneous Coronary Intervention;
Phenobarbital;
Risk Factors;
Vascular Cell Adhesion Molecule-1
- From:Korean Journal of Medicine
2008;74(1):51-58
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND/AIMS: Inflammation plays a key role in the pathogenesis and progression of cardiovascular disease (CAD). A small number of recent studies reported anti-inflammatory therapy achieved a reduction of CAD progression. The aim of the present study was to explore the roles of inflammatory markers and the conventional risk factors for CAD progression. METHODS: One hundred and fifty patients (58+/-10 years, 112 men) who underwent percutaneous coronary intervention and follow-up angiography (mean duration, 7.5+/-2.0 months) were enrolled in this study. On comparison of the coronary angiographic findings, the patients were divided into the progression and non-progression groups. The serologic inflammatory markers were angiography measured at the time of follow up. The clinical characteristic and inflammatory markers were compared between the two groups and the independent predictors of CAD progression were analyzed. CAD progression was defined as more than 30% diameter reduction of a pre-existing luminal stenosis. RESULTS: CAD progression occurred in 32 patients (21.3%). The frequency of diabetes mellitus (37.5% versus 19.5%, respectively, p=0.033) and the number of the disease vessels (p=0.003) were higher in the CAD progression group. In terms of the inflammatory markers, the progression patients had higher hsCRP (p=0.023), MCP-1 (p=0.036), sVCAM-1 (p=0.000), sP-selectin (p=0.000) and sCD40L (p=0.001) levels. Multiple logistic regression analysis of the variables showed that the logCRP (relative risk (RR) 5.016, CI=1.384-18.177, p=0.014) logVCAM-1 (RR 11.854, CI=1.883-74.614, p=0.008) and triple vessel disease of the coronary arteries (RR 5.037, CI=1.550-16.350, p=0.007) were independent predictors of CAD progression. CONCLUSION: In the present study, the extent of coronary artery disease and inflammatory markers like hsCRP and VCAM-1 were independent predictors for the progression of atherosclerotic lesions.
