Reference Values for Cystatin C Serum Concentrations in Children.
- Author:
Hyewon HAHN
1
;
Kyung Mi PARK
;
Il Soo HA
;
Hae Il CHEONG
;
Yong CHOI
;
Jeong Han SONG
Author Information
1. Department of Pediatrics, Seoul National University Children's Hospital, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Glomerular filtration rate;
Creatinine;
Cystatin C;
Reference interval
- MeSH:
Biomarkers;
Child*;
Creatinine;
Cystatin C*;
Female;
Filtration;
Glomerular Filtration Rate;
Humans;
Kidney Diseases;
Reference Values*
- From:Korean Journal of Nephrology
2001;20(1):75-79
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Cystatin C is a non-glycated 13-kilodalton basic protein produced by all nucleated cells. It has received considerable attention over the last few years as a potential replacement for creatinine as a biochemical marker for glomerular filtration rate(GFR). Recently published studies have shown that cystatin C correlates more strongly than creatinine with GFR. The aim of this study was to define a reference interval for cystatin C concentrations in children. Cystatin C was measured by an immunonephelometric assay in sera obtained from 102 children(47 boys, 55 girls, range from 1 year to 15 years) without evidence of kidney disease. The reference interval was calculated non-parametrically using the 2.5 th and 97.5th percentiles. Cystatin C concentration was constant regardless of age and sex, with a reference interval of 0.512-1.104mg/L. In contrast, serum creatinine concentration increased steadily with age until adulthood. Cystatin C offers easier recognition of renal function in childhood because its reference value is constant through all ages beyond 1 year.
