Effect of BCG Immunotherapy on the Cytokine Production and Antitumor Activity against MBT - 2 Mouse Bladder Tumor.
- Author:
Hyun Chul LEE
;
Jong Suk OH
;
Boo Ahn SHIN
;
In Chol KANG
;
Jang Ki SUH
;
Kwang Sung PARK
;
Keong A RHO
;
Soo Bang RYU
- Publication Type:Original Article
- MeSH:
Animals;
Bacillus;
Carcinoma, Transitional Cell;
Cytokines;
Immunotherapy*;
Macrophages;
Mice*;
Mycobacterium bovis*;
Urinary Bladder Neoplasms*;
Urinary Bladder*
- From:Korean Journal of Immunology
1997;19(1):157-169
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Antitumor effects of Bacillus Calmette-Guerin (BCG) against superficial urinary bladder cancer is known to be strong when BCG is directly infused into the bladder, but its immunological mechanisms are poorly understood. These experiments were performed to elucidate the effects of intralesional or systemic administration of BCG on the antitumor activity in murine transitional cell carcinoma (MBT-2) model and on the production of cytokines by the activated splenocytes or macrophages. ...continue...
