A case of lymphoepithelioma-like carcinoma of the uterine cervix.
- Author:
Mi Lyoung KIM
1
;
Hang Jo YOU
;
Eun Suk YOON
;
Sung Hyuk SIM
;
Bon Sang KOO
;
Won Duk JOO
;
Hee Jeong CHA
;
Hyun Woo LEE
Author Information
1. Department of Obstetrics & Gynecology, Ulsan University Hospital, Ulsan, Korea. dryu0210@naver.com
- Publication Type:Case Report
- Keywords:
Lymphoepithelioma-like carcinoma (LELC);
Uterine cervix
- MeSH:
Asian Continental Ancestry Group;
Carcinoma, Squamous Cell;
Cervix Uteri*;
Female;
Herpesvirus 4, Human;
Humans;
Lymph Nodes;
Lymphocytes;
Nasopharynx;
Neoplasm Metastasis;
Papilloma;
Plasma Cells;
Prognosis;
Risk Factors
- From:Korean Journal of Obstetrics and Gynecology
2007;50(1):207-211
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Lymphoepithelioma-like carcinoma (LELC) of the uterine cervix is a rare tumor with 0.7% of all primary cervical malignancies. It may grossly range from no visible cervical lesion to a large exophytic cervical mass and histologically similar neoplasms occur in the nasopharynx. It has been classified as a subtype of squamous cell carcinoma. But, after reviewing the literature, this tumor is a distinct carcinoma of the cervix that differs from squamous cell carcinoma. LELC is composed of undifferentiated cells surrounded by a marked inflammatory infiltrate, characterized by plasma cells and lymphocytes in the stroma. It may represent a better prognostic group than the more common squamous cell carcinoma of the cervix because of lack of lymph node metastasis. Typically affects a younger population of women, is more prevalent in noncaucasian population (especially, those of Asian descent). However, it is not clearly understood, Epstein-Barr virus play in the pathogenesis of cervical LELC while humam papilloma virus (HPV) is a risk factor for squamous cell carcinoma. The prognosis is good only by surgical treatment. Radiation therapy also appears to be effective in eradicating localized, low-stage disease (radiosensitive). The authors have experienced one case of LELC of the uterine cervix. We report a case with a brief review.
