The Effects of Helicobacter pylori on the prognosis of patients with curatively resected gastric cancers in a population with high infection rate.
10.4174/jkss.2012.83.4.203
- Author:
Hoon HUR
1
;
Sang Rim LEE
;
Yi XUAN
;
Young Bae KIM
;
Young Ae LIM
;
Yong Kwan CHO
;
Sang Uk HAN
Author Information
1. Department of Surgery, Ajou University School of Medicine, Suwon, Korea. hansu@ajou.ac.kr
- Publication Type:Original Article
- Keywords:
Helicobacter pylori;
Stomach neoplasm;
Prognosis;
Survival
- MeSH:
Adenocarcinoma;
Disease-Free Survival;
Enzyme-Linked Immunosorbent Assay;
Helicobacter;
Helicobacter pylori;
Humans;
Immunoglobulin G;
Prognosis;
Recurrence;
Serologic Tests;
Stomach Neoplasms
- From:Journal of the Korean Surgical Society
2012;83(4):203-211
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: The goal of this study was to assess the correlation between the Helicobacter pylori status of patients who underwent curative resection for gastric adenocarcinoma and their prognosis in Eastern societies where H. pylori infection is prevalent. METHODS: Between 2006 and 2007, 192 patients who had a curative resection for the treatment of gastric adenocarcinoma were enrolled in the study. Of these patients, 18 were excluded due to an inexact evaluation of the H. pylori status, thereby leaving 174 patients in the final analysis. Serologic testing for H. pylori was assessed using an enzyme-linked immunosorbent assay kit for immunoglobulin G, and the histological presence of H. pylori was identified using the Giemsa stain. RESULTS: Of the 174 patients, 111 patients (63.8%) were confirmed for H. pylori infection. H. pylori status did not correlate with the overall or disease-free survival. For patients with stage III or IV gastric cancer, a positive H. pylori status was a significant predictive factor for recurrence over that of a negative H. pylori status (P = 0.019). Negative H. pylori status was a predictive factor for recurrence in multivariable analysis (relative risk, 2.724; 95 confidence interval, 1.192 to 6.228). CONCLUSION: Helicobacter pylori status did not correlate with the clinicopathologic factors of gastric adenocarcinoma. However, a negative Helicobacter pylori status may be a predictive factor for recurrence in patients diagnosed with advanced gastric adenocarcinoma.
