Transfusion Premedication: A Single Center Study.
- Author:
Bo Ram KIM
1
;
Jae Lim CHOI
;
Ji Eun KIM
;
Kwang Sook WOO
;
Jung Man KIM
;
Jin Yeong HAN
;
Kyeong Hee KIM
Author Information
1. Department of Laboratory Medicine, Dong-A University College of Medicine, Busan, Korea. progreen@dau.ac.kr
- Publication Type:Multicenter Study ; Original Article
- Keywords:
Premedication;
Transfusion reaction;
Febrile non-hemolytic transfusion reaction;
Allergic transfusion reaction
- MeSH:
Acetaminophen;
Blood Group Incompatibility;
Blood Transfusion;
Chlorpheniramine;
Diphenhydramine;
Premedication;
Retrospective Studies;
Sample Size
- From:Korean Journal of Blood Transfusion
2013;24(2):121-127
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Acute transfusion reaction occurs during or within a few hours of transfusion with 0.5~3% of blood transfusion. Febrile non-hemolytic transfusion reactions (FNHTRs) and allergic transfusion reactions (ATRs) are the most common transfusion reactions. Premedication with acetaminophen and diphenhydramine has been used to prevent these reactions in 50~80% of transfusions. The purpose of this study was to describe the frequency of premedication and FNHTRs and ATRs according to premedication in Korea. METHODS: Between January 1 and 31, 2013, analysis of the first transfusion was performed retrospectively with chart review. A total of 549 cases were analyzed with regard to product of blood, care area, premedication, and FNHTRs and ATRs. RESULTS: Premedication was administered in 88.2% (484/549) of transfusions; 4 mg chlorphenamine, a well-known antihistamine, was used as premedication in all cases. Occurrence of FNHTRs was 7.7% without premedication and 3.7% with premedication. Occurrence of ATRs was 0% without premedication and 0.8% with premedication. The frequency of premedication was related to care area but not blood products. CONCLUSION: Premedication use was more frequent than previously reported. However, the sample size in this study is small; therefore, conduct of further prospective multicenter studies is needed.
