Interleukin-33, matrix metalloproteinase-9, and tissue inhibitor of matrix metalloproteinase-1 in myocardial infarction.
10.3904/kjim.2013.28.2.165
- Author:
Savas GUZEL
1
;
Ozden SERIN
;
Eda Celik GUZEL
;
Banu BUYUK
;
Guzin YILMAZ
;
Guvenc GUVENEN
Author Information
1. Department of Biochemistry, Namik Kemal University Faculty of Medicine, Tekirdag, Turkey. savasguzel@yahoo.com
- Publication Type:Original Article
- Keywords:
Inflammation;
Interleukin-33;
Matrix metalloproteinase 9;
Myocardial infarction
- MeSH:
Adult;
Angina, Unstable/blood/*enzymology/*immunology;
Biological Markers/blood;
C-Reactive Protein/metabolism;
Case-Control Studies;
Disease Progression;
Female;
Humans;
Inflammation Mediators/*blood;
Interleukins/*blood;
Male;
Matrix Metalloproteinase 9/*blood;
Middle Aged;
Myocardial Infarction/blood/*enzymology/*immunology;
Time Factors;
Tissue Inhibitor of Metalloproteinase-1/*blood
- From:The Korean Journal of Internal Medicine
2013;28(2):165-173
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND/AIMS: Acute coronary syndrome (ACS) is characterized by increased inflammatory processes and endothelial activation. We investigated the association between ACS and inflammatory mediators and matrix-degrading enzymes. METHODS: We prospectively enrolled 55 consecutive patients with ACS: 25 with unstable angina (UA) and 30 with non-ST elevated myocardial infarction (NSTEMI). For comparison, 25 age- and sex-matched subjects with no significant coronary artery stenosis were included as the control group. Peripheral serum levels of interleukin (IL)-33, matrix metalloproteinase (MMP)-9, tissue inhibitor of MMP-1, and C-reactive protein (CRP) were measured on admission, and at 12, 24, 48, and 72 hours after the initial evaluation. RESULTS: Compared to serum levels in the control group, serum levels of IL-33 decreased in the NSTEMI group (p < 0.05), and levels of MMP-9 and tissue inhibitor of matrix metalloproteinase (TIMP)-1 increased in the UA group (p < 0.01, p < 0.05, respectively) and NSTEMI group (p < 0.05, p < 0.05, respectively). IL-33 levels were significantly lower on admission than at 12 hours after the initial evaluation (p < 0.05). IL-33 levels were negatively correlated with MMP-9 levels (r = -0.461, p < 0.05) and CRP levels (r = -0.441, p < 0.05). CONCLUSIONS: Elevated levels of MMP-9, TIMP-1, and decreased levels of IL-33 play a role in the development and progression of ACS.
