Effects of genetic polymorphisms of apolipoprotein A1 on serum HDL cholesterol level in postmenopausal Korean women.
- Author:
Sang Yong EOM
1
;
Yong Dae KIM
;
Heon KIM
;
Jang Soo HONG
Author Information
1. Department of Preventive Medicine and Medical Research Institute, College of Medicine, Chungbuk National University, Cheongju 361-763, Korea.
- Publication Type:Original Article
- Keywords:
apolipoprotein A1;
genetic polymorphism;
high density lipoprotein cholesterol
- MeSH:
Alcohol Drinking;
Apolipoprotein A-I*;
Apolipoproteins*;
Body Mass Index;
Cholesterol;
Cholesterol, HDL*;
Diabetes Mellitus;
Female;
Genetic Markers;
Humans;
Hypertension;
Linkage Disequilibrium;
Lipoproteins;
Mass Screening;
Polymorphism, Genetic*;
Polymorphism, Single Nucleotide;
Smoke;
Smoking
- From:Journal of Biomedical Research
2013;14(2):105-110
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Apolipoprotein A1 (ApoA1) is the major protein component of high density lipoprotein (HDL) cholesterol in blood, and ApoA1 genetic polymorphisms modulate the blood lipid profiles. This study was conducted in order to investigate the association between three genetic polymorphisms (rs670, rs5069, and rs5070) of ApoA1 and blood lipid profiles in postmenopausal Korean women. A total of 130 postmenopausal women who visited a hospital in order to undergo screening tests were subjects of this study. Genetic polymporphisms and blood lipid profiles were determined using a direct sequencing and spectrophotometric assay, respectively. A significant linkage disequilibrium was observed between all tested single nucleotide polymorphisms. ApoA1 rs5070 genetic polymorphism showed a marginally significant association with HDL cholesterol levels (p=0.066). After adjusting for age, body mass index, smoking, alcohol drinking, medication, hypertension, and diabetes mellitus, we found that the ApoA1 rs5070 genetic polymorphism is a significant determinant of HDL cholesterol levels (beta=4.421, p=0.037). According to the results of this study, ApoA1 rs5070 genetic polymorphism may be an important genetic marker associated with HDL cholesterol in postmenopausal Korean women.
