Diagnostic and prognostic value of preoperative ¹⁸F-fluorodeoxyglucose positron emission tomography/computed tomography for colorectal cancer: comparison with conventional computed tomography.
- Author:
Joo Young LEE
1
;
Soon Man YOON
;
Jeong Tae KIM
;
Ki Bae KIM
;
Mi Jin KIM
;
Jae Geun PARK
;
Taek Gu LEE
;
Sang Jeon LEE
;
Sung Soo KOONG
;
Joung Ho HAN
;
Hee Bok CHAE
;
Seon Mee PARK
;
Sei Jin YOUN
Author Information
- Publication Type:Original Article
- Keywords: Positron-emission tomography; Computed tomography; Colorectal neoplasms; Diagnosis; Prognosis
- MeSH: Colorectal Neoplasms*; Diagnosis; Electrons*; Humans; Lymph Nodes; Neoplasm Metastasis; Positron-Emission Tomography; Prognosis; Recurrence; Sensitivity and Specificity
- From:Intestinal Research 2017;15(2):208-214
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND/AIMS: ¹⁸F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) has been used for preoperative staging of colorectal cancer (CRC). However, the diagnostic accuracy of FDG-PET/CT for detection of lymph node or distant metastasis and its prognostic role have not been well established. We therefore evaluated the diagnostic and prognostic value of FDG-PET/CT in comparison with conventional CT for CRC. METHODS: We investigated 220 patients who underwent preoperative FDG-PET/CT and CT, followed by curative surgery for CRC. The sensitivity, specificity, accuracy, positive predictive value, and negative predictive value of FDG-PET/CT and CT for detection of lymph node metastasis and distant metastasis were evaluated. In addition, we assessed the findings of FDG-PET/CT and CT according to outcomes, including cancer recurrence and cancer-related death, for evaluation of prognostic value. RESULTS: For detection of lymph node metastasis, FDG-PET/CT had a sensitivity of 44%, a specificity of 84%, and an accuracy of 67%, compared with 59%, 65%, and 62%, respectively, for CT (P=0.029, P=0.000, and P=0.022). For distant metastasis, FDG-PET/CT had a sensitivity of 79%, a specificity of 94%, and an accuracy of 93%, compared with 79%, 87%, and 86%, respectively, for CT (P=1.000, P=0.004, and P=0.037). In addition, positive findings of lymph node metastasis and distant metastasis on FDG-PET/CT were associated significantly with cancer recurrence or cancer-related death (P=0.009, P=0.001, respectively). CONCLUSIONS: Preoperative FDG-PET/CT had a higher specificity and accuracy compared to CT for detection of lymph node metastasis and distant metastasis of CRC. In addition, FDG-PET/CT could be a valuable prognostic tool for CRC.
