Malignant Gastrointestinal Stromal Tumor of the Ampulla of Vater: A Case Report.
- Author:
Su Ho KIM
1
;
Jong Hyeok KIM
;
Gwang Ho BAIK
;
Ilhyun BAEK
;
Taeho HAHN
;
Soon Ok OH
;
Jin Bong KIM
;
Sang Hoon PARK
;
Woong Ki CHANG
;
Dong Joon KIM
;
Choong Kee PARK
;
Hye Rim PARK
Author Information
1. Department of Internal Medicine, Hallym University College of Medicine, Chuncheon, Korea. kjh825@hallym.or.kr
- Publication Type:Case Report
- Keywords:
Gastrointestinal stromal tumor;
Ampulla of Vater;
Melena
- MeSH:
Adult;
*Ampulla of Vater;
Common Bile Duct Neoplasms/*diagnosis/pathology;
Female;
Gastrointestinal Stromal Tumors/*diagnosis/pathology;
Humans
- From:The Korean Journal of Gastroenterology
2004;43(1):66-70
- CountryRepublic of Korea
- Language:English
-
Abstract:
GIST is a rare neoplasm, the majority of GISTs are located in the stomach and small intestine. Most GISTs are diagnosed histopathologically after resection because of submucosal location. A 37-year-old female patient presented with a 2-weeks history of generalized weakness, nausea accompanied by intermittent passage of black, tarry stools. Esophagogastroduodenoscopy and ERCP showed a large round mass measuring 5 cm in diameter in the ampulla of Vater with ulcer crack. Endoscopic multiple biopsies from the mass including ulcer base were taken. Light microscopic findings showed spindle-shaped and epitheloid tumor cells having high cellularity and frequent mitotic figures. On immunohistochemical stainings, the tumor cells were positive for CD34 and smooth muscle actin. Based on these preoperative findings, a diagnosis of malignant GIST of the ampulla of Vater was made probably. After operation, immunohistochemical studies revealed positive reaction for c-kit and vimentin, as well as focally reactive for CD34 and smooth muscle actin. We report a case of GIST in the ampulla of Vater presenting with melena that was diagnosed preoperatively and postoperatively.
