Activated Protein C Resistance and Factor V Leiden Mutation in Patients with Arterial Ischemic Stroke.
- Author:
Sang Jin BYUN
1
;
Te Gyu LEE
;
Jun Won LEE
;
Dae Il CHANG
;
Kyung Cheon CHUNG
Author Information
1. Department of Neurology, College of Medicine, Kyung Hee University.
- Publication Type:Original Article
- Keywords:
Activated Protein C Resistance;
Factor V Leiden Mutation;
Arterial Ischemic Stroke
- MeSH:
Activated Protein C Resistance*;
Factor V*;
Hispanic Americans;
Humans;
Leukocytes;
Partial Thromboplastin Time;
Plasma;
Prevalence;
Protein C;
Risk Factors;
Stroke*;
Venous Thrombosis
- From:Journal of the Korean Neurological Association
2000;18(4):390-393
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: In the western hemisphere, resistance to activated protein C (APCR) is the most common risk factor for venous thromboembolic disease. A one-point mutation in the coagulation factor V that renders it APCR is found in more than 90% of patients with APC-resistant venous thrombosis. In Hispanic and Caucasian patients with arterial ischemic stroke, the prevalence of APC-R is approximately 10%. To determine the prevalence of APC resistance and its causative factor V mutation (Arg 506 Gln) in Koreans, we screened a group of Korean ischemic stroke patients. METHODS: We evaluated 60 Korean patients with arterial ischemic stroke diagnosed by either magnetic resonance neu-roimaging, conventional angiogram, or both, after 2 weeks of symptom onset. The mean age of the subjects was 59.2 years (13-82 years). APC resistance was expressed as a ratio of the activated partial thromboplastin time (aPTT) with and without adding APC to the subject's plasma. The presence of the factor V Leiden (Arg 506 Gln) mutation was determined by a direct polymerase chain reaction-based assay on peripheral blood leukocytes. RESULTS: Only one patient (n=1/60, 1.6%) had APC resistance and none were found to have the factor V Leiden (Arg 506 Gln) mutation. CONCLUSIONS: APCR and the factor V Leiden mutation do not seem to be a significant genetic risk factor for arterial ischemic stroke in Koreans.
