Serotonin and pancreatic duct function.
10.3346/jkms.2000.15.S.S27
- Author:
Satoru NARUSE
1
;
Atsushi SUZUKI
;
Hiroshi ISHIGURO
;
Motoji KITAGAWA
;
Shigeru BH KO
;
Toshiyuki YOSHIKAWA
;
Akiko YAMAMOTO
;
Hiroyuki HAMADA
;
Tetsuo HAYAKAWA
Author Information
1. Internal Medicine II, Nagoya University School of Medicine, Japan. snaruse@med.nagoya-u.ac.jp
- Publication Type:Original Article
- Keywords:
Pancreatic Duct;
Serotonin (5-HT);
Fluid Secretion;
Secretin;
Acethylcholine
- MeSH:
5-Methoxytryptamine/pharmacology;
Acetylcholine/pharmacology;
Animal;
Calcium/metabolism;
Guinea Pigs;
Pancreatic Ducts/metabolism*;
Pancreatic Ducts/drug effects;
Secretin/pharmacology;
Serotonin/pharmacology;
Serotonin/metabolism*;
Serotonin/analogs & derivatives*;
Vasodilator Agents/pharmacology
- From:Journal of Korean Medical Science
2000;15(Suppl):S27-S28
- CountryRepublic of Korea
- Language:English
-
Abstract:
1. 5-HT inhibits spontaneous fluid secretion as well as stimulated secretion with secretin (cAMP mediated) or ACh (Ca2+ mediated) in the isolated guinea pig pancreatic ducts. 2. The inhibitory effect of 5-HT is reversible and is dependent on the concentration in the range 0.01-0.1 microM, which is much lower than those that affect intestinal motility and secretion. 3. The 5-HT3 receptor in duct cells appears to mediate the inhibitory effect of 5-HT. 4. [Ca2+]i is unlikely to mediate the inhibitory effect of 5-HT.
