Treatment of Hemangiopericytoma-Associated Hypoglycemia with Glucocorticoid Therapy.
10.12701/yujm.2011.28.1.77
- Author:
Sung Woo PARK
1
;
Dong Geun KIM
;
Myung Jin KIM
;
Hyo Jin JANG
;
Se Hoon SOHN
;
Sung Ae KOH
;
Ha Young LEE
;
Min Kyoung KIM
;
Kyoung Hee LEE
;
Myung Soo HYUN
Author Information
1. Department of Internal Medicine, College of Medicine, Yeungnam University, Daegu, Republic of Korea. hms@med.yu.ac.kr
- Publication Type:Case Report
- Keywords:
Hemangiopericytoma;
Hypoglycemia;
Prednisolone
- MeSH:
Adrenal Glands;
Axis, Cervical Vertebra;
Fibrosarcoma;
Glucocorticoids;
Gluconeogenesis;
Growth Hormone;
Hemangiopericytoma;
Humans;
Hypoglycemia;
Insulin-Like Growth Factor II;
Kidney;
Liver;
Mesothelioma;
Neurofibroma;
Prednisolone;
Stress, Psychological
- From:Yeungnam University Journal of Medicine
2011;28(1):77-83
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Non-islet cell tumor-induced hypoglycemia (NICTH) is associated with mesenchymal tumor types, including hemangiopericytoma, fibrosarcoma, mesothelioma, and neurofibroma, as well as carcinoma of the liver, adrenal glands, and kidneys. Non-islet cell tumors induce hypoglycemia by overproducing an abnormal form of insulin-like growth factor II (IGF II). Complete removal of the tumor or reduction of the tumor mass is a successful therapeutic strategy in cases of NICTH. However, if the tumor re-grows, curative resection is nearly impossible, and hypoglycemia occurs repeatedly. Glucocorticoids are effective in terms of long-term relief from hypoglycemia through promotion of gluconeogenesis in the liver, tumor suppression, production of 'big'-IGF-II, and correction of the attendant biochemical abnormalities involving the growth hormone (GH)-IGF axis. We found that administration of corticosteroid therapy to a patient suffering from NICTH resulted in improvement of hypoglycemia associated symptoms.
