Clinical pharmacokinetics of norfloxacin-glycine acetate after intravenous and oral administration in pigs.
- Author:
Zhi Qiang CHANG
1
;
Byung Chol OH
;
Jong Choon KIM
;
Kyu Shik JEONG
;
Myung Heon LEE
;
Hyo In YUN
;
Mi Hyun HWANG
;
Seung Chun PARK
Author Information
- Publication Type:Original Article ; Clinical Trial ; Research Support, Non-U.S. Gov't
- Keywords: norfloxacin; pharmacokinetics; pig
- MeSH: Administration, Oral; Animals; Anti-Bacterial Agents/administration & dosage/blood/*pharmacokinetics; Biological Availability; Cross-Over Studies; Glycine/administration & dosage/*analogs & derivatives/blood/pharmacokinetics; Half-Life; Injections, Intravenous/veterinary; Male; Norfloxacin/administration & dosage/*analogs & derivatives/blood/pharmacokinetics; Swine/*metabolism; Time Factors
- From:Journal of Veterinary Science 2007;8(4):353-356
- CountryRepublic of Korea
- Language:English
- Abstract: The pharmacokinetics and dosage regimen of norfloxacin-glycine acetate (NFLXGA) was investigated in pigs after a single intravenous (i.v.) or oral (p.o.) administration at a dosage of 7.2 mg/kg body weight. After both i.v. and p.o. administration, plasma drug concentrations were best fitted to an open two-compartment model with a rapid distribution phase. After i.v. administration of NFLXGA, the distribution (t1/2alpha) and elimination half-life (t1/2beta) were 0.36 +/- 0.07 h and 7.42 +/- 3.55 h, respectively. The volume of distribution of NFLXGA at steady state (Vdss) was 4.66 +/- 1.39 l/kg. After p.o. administration of NFLXGA, the maximal absorption concentration (Cmax) was 0.43 +/- 0.06 microgram/ ml at 1.36 +/- 0.39 h (Tmax). The mean absorption (t1/2ka) and elimination half-life (t1/2beta) of NFLXGA were 0.78 +/- 0.27 h and 7.13 +/- 1.41 h, respectively. The mean systemic bioavailability (F) after p.o. administration was 31.10 +/- 15.16%. We suggest that the optimal dosage calculated from the pharmacokinetic parameters is 5.01 mg/kg per day i.v. or 16.12 mg/kg per day p.o.
