Prevalence and Risk Factors of Colorectal Adenoma in 14,932 Koreans Undergoing Screening Colonoscopy.
10.4166/kjg.2013.62.2.104
- Author:
Hee Sun KIM
1
;
Su Jung BAIK
;
Kyung Hee KIM
;
Cho Rong OH
;
Sang In LEE
Author Information
1. Health Promotion Center, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea. aderheesun@yuhs.ac
- Publication Type:Original Article ; English Abstract
- Keywords:
Colorectal adenoma;
Helicobacter pylori;
Occult blood;
Triglycerides;
Colonoscopy
- MeSH:
Adenoma/*epidemiology/etiology;
Adult;
Age Factors;
Aged;
Aged, 80 and over;
Asian Continental Ancestry Group;
Colonoscopy;
Colorectal Neoplasms/*epidemiology/etiology;
Female;
Helicobacter Infections/complications;
Helicobacter pylori;
Humans;
Hypertriglyceridemia/complications;
Logistic Models;
Male;
Middle Aged;
Odds Ratio;
Republic of Korea/epidemiology;
Retrospective Studies;
Sex Factors
- From:The Korean Journal of Gastroenterology
2013;62(2):104-110
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND/AIMS: Current international guidelines recommend colorectal cancer screening for average-risk people over 50 years of age. Accordingly, we aimed to estimate the prevalence of colorectal neoplasms in all age groups and evaluate associated risk factors. METHODS: Data of 14,932 subjects who underwent colonoscopy from July 2006 to January 2012 at Health Promotion Center, Gangnam Severance Hospital (Seoul, Korea) as part of a health check-up were reviewed retrospectively. RESULTS: The overall prevalence of colorectal neoplasms and adenoma were 34.6% and 25.3%, respectively. Colorectal adenoma was found in 3.2%, 13.0%, 21.7%, 33.8%, 44.0%, 50.5%, and 54.2% of subjects under 30 years, 30-39 years, 40-49 years, 50-59 years, 60-69 years, 70-79 years, and over 80 years of age (trend p<0.0001). Independent predictors of colorectal adenoma included male gender (OR 2.38, 95% CI 2.084-2.718), positive occult blood (2.266, 1.761-2.917), positive serology of Helicobacter pylori (1.253, 1.114-1.409) and hypertriglyceremia (1.267, 1.065-1.508). Compared to the 30-39 years of age reference group, the ORs for each age group were 0.195 (under 30 years), 1.634 (40-49 years), 2.954 (50-59 years), 5.159 (60-69 years), 5.640 (70-79 years), 11.020 (over 80 years), while the 95% CIs were 0.071-0.536 (under 30 years), 1.340-1.992 (40-49 years), 2.421-3.604 (50-59 years), 4.109-6.476 (60-69 years), 3.822-8.322 (70-79 years), and 2.809-42.234 (over 80 years). CONCLUSIONS: Colorectal adenoma prevalence increased proportionally with age. Only subjects under the age of 30 years had a definitely lower prevalence of colorectal adenoma. Male gender, positive occult blood, positive serology of H. pylori, and hypertriglyceremia were associated risk factors of colorectal adenoma.
