Primary Mucosa-associated Lymphoid Tissue Lymphoma of the Esophagus, Manifesting as a Submucosal Tumor.
10.4166/kjg.2013.62.2.117
- Author:
Jae Gu JUNG
1
;
Hyoun Woo KANG
;
Suk Jae HAHN
;
Jong Sun CHOI
;
Eung Joong KIM
Author Information
1. Department of Internal Medicine, Dongguk University Ilsan Hospital, Goyang, Korea. gangmali@naver.com
- Publication Type:Case Reports
- Keywords:
Esophagus;
Lymphoma;
B-Lymphocytes;
Marginal zone B-cell lymphoma
- MeSH:
Antigens, CD20/metabolism;
Bone Marrow/pathology;
Esophageal Neoplasms/*diagnosis/pathology/surgery;
Gastroscopy;
Humans;
Immunohistochemistry;
Lymphoma, B-Cell, Marginal Zone/*diagnosis/pathology/surgery;
Male;
Middle Aged;
Mucous Membrane/pathology;
Proto-Oncogene Proteins c-bcl-2/metabolism;
Tomography, X-Ray Computed
- From:The Korean Journal of Gastroenterology
2013;62(2):117-121
- CountryRepublic of Korea
- Language:English
-
Abstract:
We report a case of primary mucosa-associated lymphoid tissue (MALT) lymphoma in the esophagus that manifested as a large submucosal tumor (SMT). Primary esophageal lymphoma is very rare, occurring in less than 1% of all patients with gastrointestinal lymphoma. Only a few cases of MALT lymphoma in the esophagus have been reported in the English literature. A 53-year-old man was referred to Dongguk University Ilsan Hospital (Goyang, Korea) in July 2012 for further evaluation and treatment of an esophageal SMT. Endoscopy showed a cylindrically elongated submucosal mass with normal overlying mucosa in the mid esophagus, 25-30 cm from the incisor teeth. He underwent surgery to confirm the diagnosis. Pathologic findings showed diffuse small atypical lymphoid cells which were stained with Bcl-2, CD20, but not with CD3, CD5, CD23, Bcl-6, or cyclin D1. These cells showed a positive monoclonal band for immunoglobulin heavy chain gene rearrangement. Based on the pathological, immunohistochemical, and molecular biological features, the esophageal mass was diagnosed as extranodal marginal zone B-cell lymphoma of the MALT type.
