Auto-immune Response in Degenerated Lumbar Disk.
- Author:
Nam Hyun KIM
1
;
Eung Shick KANG
;
Chang Dong HAN
;
Joo Deuk KIM
;
Chang Hee KIM
Author Information
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords: Disk; Autoimmunity
- MeSH: Adolescent; Adult; Autoimmune Diseases/complications*; Back Pain/etiology; Back Pain/immunology*; Child; Female; Human; Immunoglobulins/analysis; Intervertebral Disk*; Male; Middle Age; Spinal Diseases/immunology*
- From:Yonsei Medical Journal 1981;22(1):26-32
- CountryRepublic of Korea
- Language:English
- Abstract: The serum level of Ig G, Ig M, Ig A, Ig D and C3 were determined by a Hyland Immunodiffusion plate in 60 patients and 29 normal healthy controls. Immunoglobulin G level was increased only in patient's with herniated nucleus pulposus. We also could demonstrate high levels of Ig G in group I, the ruptured nucleus cases, but there were no differences in the levels of other immunoglobulins and C3 in other groups. In the Ochterlony gel diffusion test for the detection of humoral antibody for the nucleus pulposus, only 4 cases gave precipitation lines using antigen excised from nucleus pulposus. In 2 cases high levels of Ig G were observed. All 89 patients gave negative precipitation lines using proteoglycan as antigen.
