The Level of Serum and Urinary Nephrin in Normal Pregnancy and Pregnancy with Subsequent Preeclampsia.
10.3349/ymj.2017.58.2.401
- Author:
Yun Ji JUNG
1
;
Hee Young CHO
;
SiHyun CHO
;
Young Han KIM
;
Jin Dong JEON
;
Young Jin KIM
;
Sanghoo LEE
;
Jimyeong PARK
;
Ha Yan KIM
;
Yong Won PARK
;
Ja Young KWON
Author Information
1. Department of Obstetrics and Gynecology, Institute of Women's Life Medical Science, Yonsei University College of Medicine, Seoul, Korea. jaykwon@yuhs.ac
- Publication Type:Original Article
- Keywords:
Nephrin;
serum;
urine;
preeclampsia
- MeSH:
Enzyme-Linked Immunosorbent Assay;
Gestational Age;
Humans;
Postpartum Period;
Pre-Eclampsia*;
Pregnancy*;
Prospective Studies;
Reference Values
- From:Yonsei Medical Journal
2017;58(2):401-406
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: The aim of this study was to evaluate serum and urinary nephrin levels of normal pregnancy to establish a standard reference value and to compare them with patients who subsequently developed preeclampsia (PE). MATERIALS AND METHODS: In this prospective study, 117 healthy singleton pregnancies were enrolled between 6 to 20 weeks of gestation at 2 participating medical centers during October 2010 to March 2012. Urine and serum samples were collected at the time of enrollment, each trimester, and at 4 to 6 weeks postpartum. Enzyme-linked immunosorbent assay for nephrin was performed and samples from patients who subsequently developed PE were compared to the normal patients. RESULTS: Of 117 patients initially enrolled, 99 patients delivered at the study centers and of those patients, 12 (12.1%) developed PE at a median gestational age of 34⁺⁴ weeks (range 29⁺⁵–36⁺⁶). In the normal patients (n=68), serum nephrin level decreased and urinary nephrin level increased during the latter of pregnancy. In 12 patients who subsequently developed PE, a significant rise in the 3rd trimester serum and urinary nephrin levels, compared to the controls, was observed (p<0.001), and this increase occurred 9 days prior to the onset of clinical disease. CONCLUSION: As the onset of PE was preceded by the rise in the serum and urinary nephrin in comparison to normal pregnancy, serum and urinary nephrin may be a useful predictive marker of PE.
