Insulin Secretory Capacity and Insulin Resistance in Korean Type 2 Diabetes Mellitus Patients.
10.3803/EnM.2016.31.3.354
- Author:
Jong Dai KIM
1
;
Won Young LEE
Author Information
1. Division of Endocrinology and Metabolism, Department of Internal Medicine, Konyang University Hospital, Konyang University College of Medicine, Daejeon, Korea.
- Publication Type:Review
- Keywords:
Insulin resistance;
Diabetes mellitus, type 2;
Asian continental ancestry group
- MeSH:
Asian Continental Ancestry Group;
Diabetes Mellitus, Type 2*;
Humans;
Insulin Resistance*;
Insulin*;
Korea;
Life Style;
Obesity;
Physiology;
Prevalence
- From:Endocrinology and Metabolism
2016;31(3):354-360
- CountryRepublic of Korea
- Language:English
-
Abstract:
It is well known that many Korean patients with type 2 diabetes mellitus (T2DM) were non-obese and had decreased insulin secretion in past. However, during the past three decades, lifestyles in Korea have been westernized. As a result, the prevalence of obesity, the main cause of diabetes has increased. Thus, there is still a question as to whether the main pathophysiology of current Korean T2DM is insulin resistance or an insulin secretion defect. Because various anti-diabetes medications having different mechanisms of action are currently used as therapeutics, it is important to understand which of these factors is the main physiology in the development of diabetes in Koreans. In this review, we review changes in obesity prevalence, insulin resistance and insulin secretion defects in Korean T2DM during three decades.
