Novel Molecules Regulating Energy Homeostasis: Physiology and Regulation by Macronutrient Intake and Weight Loss.
10.3803/EnM.2016.31.3.361
- Author:
Anna GAVRIELI
1
;
Christos S MANTZOROS
Author Information
1. Department of Endocrinology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA. cmantzor@bidmc.harvard.edu
- Publication Type:Review
- Keywords:
Ghrelin;
Peptide tyrosine-tyrosine;
Islet amyloid polypeptide;
Gastric inhibitory polypeptide;
Fibroblast growth factor 21;
Chemerin;
Irisin
- MeSH:
Appetite;
Bile Acids and Salts;
Diet;
Energy Intake;
Energy Metabolism;
Fibroblast Growth Factors;
Gastric Inhibitory Polypeptide;
Ghrelin;
Heme Oxygenase-1;
Homeostasis*;
Incretins;
Islet Amyloid Polypeptide;
Obesity;
Physiology*;
Weight Loss*
- From:Endocrinology and Metabolism
2016;31(3):361-372
- CountryRepublic of Korea
- Language:English
-
Abstract:
Excess energy intake, without a compensatory increase of energy expenditure, leads to obesity. Several molecules are involved in energy homeostasis regulation and new ones are being discovered constantly. Appetite regulating hormones such as ghrelin, peptide tyrosine-tyrosine and amylin or incretins such as the gastric inhibitory polypeptide have been studied extensively while other molecules such as fibroblast growth factor 21, chemerin, irisin, secreted frizzle-related protein-4, total bile acids, and heme oxygenase-1 have been linked to energy homeostasis regulation more recently and the specific role of each one of them has not been fully elucidated. This mini review focuses on the above mentioned molecules and discusses them in relation to their regulation by the macronutrient composition of the diet as well as diet-induced weight loss.
