Retinoid Metabolism and Diabetes Mellitus.
10.4093/dmj.2012.36.3.167
- Author:
Eun Jung RHEE
1
;
Jorge PLUTZKY
Author Information
1. Department of Endocrinology and Metabolism, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.
- Publication Type:Review
- Keywords:
Diabetes mellitus;
Retinoid;
Rexinoid
- MeSH:
Autoimmunity;
Cell Survival;
Diabetes Mellitus;
Glucose;
Human Body;
Insulin;
Insulin Resistance;
Lipid Metabolism;
Prevalence;
Retinoids;
Vitamin A
- From:Diabetes & Metabolism Journal
2012;36(3):167-180
- CountryRepublic of Korea
- Language:English
-
Abstract:
Retinoid acid is a metabolite of vitamin A and functions as an important factor in cell survival, differentiation and death. Most previous studies on retinoid metabolism have focused on its association with cancer, hematologic and dermatologic disorders. Given the special concern over the recent increase in the prevalence of diabetes worldwide, the role of retinoid metabolism on glucose metabolism and insulin resistance in the human body is of marked importance. Therefore, in this issue, we review the literature on the association of retinoid metabolism with glucose tolerance, with regard to insulin secretion, pancreatic autoimmunity, insulin sensitivity and lipid metabolism. Further, we tried to assess the possibility of using retinoids as a novel therapeutic strategy for diabetes.
