Correlation of serum interleukin 8 with clinical disease activity in systemic lupus erythematosus (SLE).
- Author:
Won Ki LEE
1
;
Chang Ho SONG
;
Yong Beom PARK
;
Choong Won LEE
;
Chang Hee SUH
;
Chan Hee LEE
;
Jisoo LEE
;
Dong Soo KIM
;
Soo Kon LEE
Author Information
1. Division of Rheumatology, Department of Internal Medicine, College of Medicine, Yonsei University, Seoul, Korea
- Publication Type:Original Article
- Keywords:
systemic lupus erythematosus;
clinical disease activity;
interleukin 8
- MeSH:
Antigen-Antibody Complex;
Blood Platelets;
Enzyme-Linked Immunosorbent Assay;
Humans;
Interleukin-8*;
Interleukins*;
Leukocytes;
Lupus Erythematosus, Systemic*;
Lymphocytes;
Weights and Measures
- From:Korean Journal of Medicine
1998;54(6):770-777
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVES: To evaluate serum Interleukin 8 (IL-8) as a predictor of disease activity in SLE and to provide insight into the potential role of IL-8 in the pathogenesis of SLE. METHODS: Sixty-four paired sera from the 32 SLE patients and 10 healthy control sera were obtained. Serum IL-8 levels were determined by ELISA technique. Tests for other laboratory parameters, such as circulating immune complex (CIC), C3, C4, ANA, anti-dsDNA, Hb, Hct, leukocyte, lymphocyte, platelet and ESR, were performed for every sample coincidently with assessment of clinical disease activity by the Lahita scales. RESULTS: We found that serum IL-8 levels in SLE patients were significantly higher than those of healthy controls. Serum IL-8 levels significantly correlated with clinical disease activity. Serum IL-8 levels correlated with CIC, but it had no correlation with other laboratory parameters. CONCLUSON: These findings suggest that serum IL-8 can be used as a marker of disease activity in patients with SLE. These results may have implication in the pathogenesis of SLE.
