Systemic Lupus Erythematosus-like paraneoplastic syndrome associated with lung cancer.
- Author:
Yun Jong LEE
1
;
Ki Chul SHIN
;
Seong Wook KANG
;
Chang Wan HAN
;
Yeong Wook SONG
Author Information
1. Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
- Publication Type:Case Report
- Keywords:
Systemic lupus erythematosus;
Lung cancer;
Paraneoplastic syndrome
- MeSH:
Aged;
Arthralgia;
Cough;
Dyspnea;
Fever;
Humans;
Leukocytosis;
Lower Extremity;
Lung Neoplasms*;
Lung*;
Lupus Erythematosus, Systemic;
Lymphopenia;
Male;
Myalgia;
Naproxen;
Paraneoplastic Syndromes*;
Pericardial Effusion;
Peripheral Nervous System Diseases;
Pleural Effusion;
Proteinuria;
Recurrence
- From:Korean Journal of Medicine
1998;54(6):833-839
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Systemic lupus erythematosus (SLE) has been described very rarely in association with underlying malignancy. We experienced a 68-year-old male with systemic erythematosus lupus associated with squamous cell lung cancer. He had radiation therapy as a primary treatment modality. Ten months after the radiation therapy, he suffered from intermittent fever, myalgia, multiple arthralgia, dry cough, and dyspnea. He had leukocytosis and lymphopenia. Anti-nuclear antibody was positive. He had bilateral pleural effusion, pericardial effusion, and proteinuria (2405 mg/day). He had peripheral neuropathy with lower extremity weakness. There was no evidence of recurrence of lung cancer. He was treated with naproxen (1 gm/day) with symptomatic improvement. We describe a clinical course of paraneoplastic SLE in patient with lung cancer, and review the literatures.
