T Cells in Cutaneous Lesions of Psoriasis.
- Author:
Kyu Uang WHANG
;
Chang Woo LEE
;
Sook Ja SON
;
Jae Hong KIM
;
Joong Hwan KIM
- Publication Type:Original Article
- Keywords:
Psoriasis;
T cells;
Immunoperoxidase technique ( OKT )
- MeSH:
Dermis;
Humans;
Leukocytes;
Psoriasis*;
T-Lymphocytes*
- From:Korean Journal of Dermatology
1985;23(3):279-282
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Anti-T cell monoclonal antibodies(OKT series: OKT4a OKT8A, OKT1 1) ir,amunoperoxidase technique studies were performed for the presence of T cells and their subpopulations in cutaneous lesions of early papules and late plaques from 10 patients with psoriasis. In this semiquantitative examination, T cells reactive to OKT11 antiserum constituted about 70 percents of total leukocytes found in the dermis, both in early papular lesions and late plaque lesions. The number of helper/inducer T cells was about equal to the number of suppressor/cytotoxic T cells in early papular lesions, but helper/inducer T cells were predominant in plaque lesions. Although in situ functions of T cell and their subpopulations can not precisely be deduced, this different proportions of the helper/inducer and suppressor/cytotoxic T cells found in this study might be related to the immunopathologic mechanisms pertainmg to the persistence and the expansion of psoriatic lesions.
